BUY FUB-PB22 POWDER

[Roberta Cook]

BUY FUB-PB22 POWDER is an indole-based synthetic cannabinoid that is a potent agonist of the CB1 receptor and has been sold online as a designer drug.

FUB-PB22 with the formal name of quinolin-8-yl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate and is a substitute of 5F-PB22 and PB22. The molecular formula is C25H17FN2O2 with a molecular weight of 396.41 and an exact mass of 396.13. FUB-PB22 is a white powder, developed on an indazole base, which sets it apart from several other JWH compounds having an indolyl base. At this time, research on FUB-PB22 has not determined the biochemical, physiological, and toxicological properties, thus more research is needed.

Pharmacology
FUB-PB-22 acts as a full agonist with a binding affinity of 0.386nM at CB1 and 0.478nM at CB2cannabinoid receptors.

Legal status
FUB-PB-22 is a Anlage II controlled substance in Germany. It was scheduled in Japan in July 2014.

As of October 2015 FUB-PB-22 is a controlled substance in China.

It is also banned in Sweden.

Chemical and physical data
Formula: C25H17FN2O2

Molar mass: 396.41 g/mol g·mol?1

See also
5F-PB-22
AM-2201
BB-22
FUB-JWH-018
AB-FUBINACA
ADB-FUBINACA
AMB-FUBINACA
FDU-PB-22
FUB-144
FUB-APINACA
MDMB-FUBICA
MDMB-FUBINACA
PB-22

https://alpharesearchlab.net/product/buy-fub-pb22-powder/

https://alpharesearchlab.net/product/buy-fub-pb22-powder/



BUY SDB-005 POWDER
SDB-005 is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. It is presumed to be an agonist of the CB1 and CB2 cannabinoid receptors. SDB-005 is the indazole core analog of PB-22 where the 8-hydroxyquinoline has also been replaced with a naphthalene group.

The code number SDB-005 was originally used for a different compound, the N-phenyl instead of N-benzyl analogue of SDB-006. This compound is a potent agonist of the CB1 receptor (Ki = 21 nM) and CB2 receptor (Ki = 140 nM).

However, SDB-005 was subsequently used as the name for the indazole-3-carboxylate compound mentioned above when it was sold in Europe as a designer drug, and was entered into the EMCDDA synthetic drug database under this name. Consequently, there are now two distinct, yet fairly closely related cannabinoid compounds, which may both be referred to under the code SDB-005.

Technical Information
Formal Name: naphthalen-1-yl 1-pentyl-1H-indazole-3-carboxylate
Molecular Formula: C23H22N2O2
Formula Weight: 358.4
Purity: ?98%
Formulation: A crystalline solid
?max: 220, 300 nm
SMILES: O=C(OC1=C(C=CC=C2)C2=CC=C1)C3=NN(CCCCC)C4=CC=CC=C43
InChi CodeInChI=1S/C23H22N2O2/c1-2-3-8-16-25-20-14-7-6-13-19(20)22(24-25)23(26)27-21-15-9-11-17-10-4-5-12-18(17)21/h4-7,9-15H,2-3,8,16H2,1H3
InChi Key: JBVNFKZVDLFOAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 2 years
WARNING This product is not for human or veterinary use.BUY SDB-005 POWDER

See also
5F-PB-22
AM-2201
BB-22
JWH-018
NM-2201
NNE1

https://alpharesearchlab.net/product/buy-sdb-005-powder/

https://alpharesearchlab.net/product/buy-sdb-005-powder/


Buy AM-2201 Powder, AM-2201 Powder, AM-2201 Powder
Buy AM-2201 Powder  AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor. It is part of the AM series of cannabinoids discovered by Alexandros Makriyannis at Northeastern University.
AM-2201 Powder is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2. The 4-methyl functional analog MAM-2201 probably has similar affinities. AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors. AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.
Product Description

AM-2201 Powder (Item No. 10707) is an analytical reference material characterized as a synthetic cannabinoid.

AM2201 is regulated as a Schedule I compound in the United States.

Abstract
Novel synthetic cannabinoids are appearing in recreational drug markets worldwide. Pharmacological characterization of these new drugs is needed to inform clinicians, toxicologists, and policy makers who monitor public health. [1-(5-Fluoropentyl)-1H-indol-3-yl](1-naphthyl)methanone (AM-2201) is an abused synthetic cannabinoid that was initially created as a research tool for investigating the endocannabinoid system.

Here we measured the pharmacodynamic effects of AM-2201 in rats, and simultaneously determined plasma pharmacokinetics for the parent drug and its metabolites. Male Sprague-Dawley rats were fitted with surgically implanted temperature transponders and indwelling jugular catheters under pentobarbital anesthesia. One week later, rats received subcutaneous injection of AM-2201 (0.1, 0.3, and 1.0 mg/kg) or its vehicle, and serial blood specimens were withdrawn via catheters. Core temperatures and catalepsy were measured just prior to each blood withdrawal, and plasma was assayed for drug and metabolites using liquid chromatography-tandem mass spectrometry.

Two new types of synthetic cannabinoids, an AM-2201 benzimidazole analog (FUBIMINA, 1) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM, 2), and three newly emerged phenethylamine derivatives, 25B-NBOMe (3), 2C-N-NBOMe (4), and a 25H-NBOMe 3,4,5-trimethoxybenzyl analog (5), were detected in illegal products distributed in Japan.

The identification was based on liquid chromatography–mass spectrometry (LC–MS) and gas chromatography–mass spectrometry (GC–MS), high-resolution MS, and nuclear magnetic resonance analyses. Different from the representative synthetic cannabinoids, such as JWH-018, which have a naphthoylindole moiety, compounds 1 and 2 were completely new.

Precautions
All of Croweed Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to Croweed that you will properly test and use any Products purchased from Croweed in accordance with industry standards. Croweed and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. Croweed reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to Croweed within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Technical Information
Formal Name: [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number: 335161-24-5
Molecular Formula: C24H22FNO
Formula Weight: 359.4
Purity: ?98%
Formulation: A neat solid
?max: 218, 247, 315 nm
SMILES: O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(CCCCCF)C4=CC=CC=C43
InChi Code: InChI=1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2

See also
AM-694
AM-1235
AM-2232
AM-2233
JWH-018
SDB-005
THJ-018
THJ-2201
MEPIRAPIM
NM-2201

Shipping & Storage Information
Storage: -20°C

https://alpharesearchlab.net/product/buy-am-2201-powder/

https://alpharesearchlab.net/product/buy-am-2201-powder/