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An analogue of MDMB-FUBINACA Powder, ADSB-FUB-187, containing a more functionalized carboxamide substituent was recently reported.
Technical Information
Formal Name: N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS Number: 1445583-51-6
Molecular Formula: C21H23FN4O2
Formula Weight: 382.4
Purity: ?98%
Formulation: A neat solid
SMILES: O=C(NC(C(N)=O)C(C)(C)C)C1=NN(CC2=CC=C(F)C=C2)C3=C1C=CC=C3
InChi CodeInChI=1S/C21H23FN4O2/c1-21(2,3)18(19(23)27)24-20(28)17-15-6-4-5-7-16(15)26(25-17)12-13-8-10-14(22)11-9-13/h4-11,18H,12H2,1-3H3,(H2,23,27)(H,24,28)
InChi Key: ZSSGCSINPVBLQD-UHFFFAOYSA-N
DEA Schedule: I
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Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
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In the United States, AMB-Fubinaca is a Schedule I controlled substance.
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Side effects
One death through coronary arterial thrombosis has been linked to AMB-Fubinaca intoxication.
At least an additional 8 deaths in Hungary in 2015 are linked to the usage of this material, all deaths were youngsters below 21.
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The (S)-enantiomer of AB-FUBINACA 2-fluorobenzyl isomer is described in a 2009 Pfizer patent and has been reported to be a potent agonist of the CB1 receptor and the CB2 receptor with EC50 values of 1.2 nM and 3.5 nM, respectively. AMB-Fubinaca Powder features a carboxamide group at the 3-indazole position, like SDB-001 and STS-135. MDMB-FUBINACA Powder appears to be the product of rational drug design, since it differs from AMB-Fubinaca only by the replacement of the isopropyl group with a tert-butyl group.
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Technical Information
Formal Name: N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS Number: 1445583-51-6
Molecular Formula: C21H23FN4O2
Formula Weight: 382.4
Purity: ?98%
Formulation: A neat solid
SMILES: O=C(NC(C(N)=O)C(C)(C)C)C1=NN(CC2=CC=C(F)C=C2)C3=C1C=CC=C3
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InChi Key: ZSSGCSINPVBLQD-UHFFFAOYSA-N
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Storage: -20°C
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Metabolism
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One death through coronary arterial thrombosis has been linked to AB-FUBINACA 2-fluorobenzyl isomer intoxication.
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BUY A-PVT POWDER (also known as ?-Pyrro?lidino?pentio?thiophenone or ?-PVT) is a synthetic stimulant of the cathinone class that has been sold online as a designer drug. It is an analogue of ?-PVP where the phenyl ring has been replaced by thiophene.
?-PVT was first identified in Japan in 2013. Its metabolism has been described in literature.
Side effects
?-PVT has been shown to possess high cytotoxicity against human cell lines
Legality
Sweden’s public health agency suggested classifying ?-PVT as hazardous substance on November 10, 2014.
As of October 2015 ?-PVT is a controlled substance in China.
?-PVT is illegal in Switzerland as of December 2015
Chemical and physical data
Formula: C13H19NOS
Molar mass: 237.36 g/mol g·mol?1
Various Uses and Effects of A-PVT
You should blend A-PVT with other substances before consuming it. Apart from that, you can inhale that as well or consume orally. The dosage should be decided by the doctor only and you should not have multiple dosages within a single hour.
Though the potency is lesser, A-PVT can be compared with cocaine. If you place it under your tongue, you will find the same to dissolve very quickly. At the same time, you may get a numb sort of feeling. Euphoria takes time to set in, but should be there within 30 minutes of the consumption. After the numbness, you will see that the blood pressure has increased mildly. You will lose any desire of drinking water at the same time as well.
When 45 minutes or more pass after consumption, you will feel a mild stimulation and you may even feel sleepy. Overall, the effects should not last for more than 3 hours and you may not feel the urge to get another dose soon.
If you go through the insufflation method, you are bound to get the euphoric feeling for a comparatively longer time period. That being said, guessing the potency is a hard thing as some patients get affected very slowly, while others get affected in a pretty fast manner. As soon as the same enters the nose of the customer, it starts to work. Within 10 minutes of consumption, you will experience euphoria (Under insufflation method). You may even experience blackouts at a frequent basis and within an hour of consumption, you should start feeling drowsy.
See also
?-Pyrrolidinopropiophenone (?-PPP)
?-Pyrrolidinobutiophenone (?-PBP)
?-Pyrrolidinohexiophenone (?-PHP)
Methiopropamine
Naphyrone (O-2482)
Pyrovalerone (O-2371)
Thiopropamine
Thiothinone
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Buy Flephedrone Crystal, also known as 4-fluoromethcathinone (4-FMC), is a stimulant drug of the cathinone chemical class that has been sold online as a designer drug starting in 2008. 4-FMC is a synthetic stimulant with mild empathogenic effects that is chemically similar to methcathinone. It and its 2- and 3- positional isomers have been identified in “legal high” products. 4-FMC has an extremely short history of human use.
Flephedrone is one of the most common recreational drugs which is the reason why the authorities all over the world have come down hard against it as it remains a banned substance in most of the European countries. It is however also legal for medical purpose in some countries and is prescribed for various medical conditions.
Toxicity
Flephedrone has only a short history of human use and its toxicity is not well established.
Street and Chemical names 4-FMC.
Flephedrone is also known as 4-FMC. It is a drug of the cathinone family having stimulant nature. In addition to stimulation, it also produces empathogenic effects in the users. The drug first became commercially available in the year 2008 as a replacement to Mephedrone but it is noted that it could not generate as much hype. The chemical formula of Flephedrone is “1-(4-Fluorophenyl)-2-(methylamino) propan-1-one” while the molecular formula is C10H12FNO. The molecular weight of Flephedrone is 181.2 g/mol.
The mode of administration of the dose is through oral, insufflation and vaporized means. The purity levels usually found for flephedrone are around 98 – 99% and it is recommended to use high-quality crystals as the presence of impurities can cause toxicity.
The standard storage temperature for flephedrone is room temperature and the drug should be stored in moisture free environment.
Street and Chemical names
The Chemical name for Flephedrone in 4-FMC (4-Fluoromethcathinone) and it is also available online and in street under various brand names other than flephedrone.
Flephedrone is a stimulant designer drug having various applications in the field of science and medicine. It is used by the researchers as a research chemical mostly in the field of forensics and mass spectrometry. In the field of medicine, it is prescribed for various medical conditions such as anxiety and depression. It is also used by the athletes as a performance enhancer drug. Owing to its significance, it can be obtained from physical and online stores around the world where it is not banned for consumption. We have made this drug available on our online store for users all over the world. Our store is among the top sellers of cathinone drugs as we provide high-quality products to our clients at highly discounted rates. We have the ability to ship the products all over the world while we keep the information of our clients safe and secure.
Chemical and physical data
Formula: C10H12FNO
Molar mass: 181.206 g/mol g·mol?1
See also
3-Fluoromethcathinone (3-FMC)
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Buy Ethylone Crystal, also known as 3,4-methylenedioxy-N-ethylcathinone (MDEC, ?k-MDEA), is a recreational designer drug classified as an entactogen, stimulant, and psychedelic of the phenethylamine, amphetamine, and cathinone chemical classes. It is the ?-keto analogue of MDEA (“Eve”). Ethylone has only a short history of human use and is reported to be less potent than its relative methylone. In the United States, it began to be found in cathinone products in late 2011.
Very little data exists about the pharmacological properties, metabolism, and toxicity of ethylone, and although several ethylone-related deaths have been reported, but the cause of death was not due to ingestion of ethylone.
Description
The compound is administered in different ways. The two main ones are orally and intranasally. When administered orally, the substance is more effective, which is possible thanks to high 5HT serotonin receptors concentration. Some of the positive effects after you buy Ethylone online include color enhancements and boundaries softening, increased appreciation for music and people, who surround you, stimulation and euphoria, a few entactogenic and empathy effects. While these are positive influences, here are some negative ones: depression and severe paranoia, hypertension in people with heart problems and diseases, anxiety and nausea in rare cases.
When it is taken orally, Ethylone for sale starts acting within half an hour after administration. First feelings are stimulation and euphoria. Others occur, depending on the dosage. The peak of effects is reached in an hour or more. The effects resemble those of MDMA, yet they aren’t as potent as the latter ones. This peak may hold on for about 3 or 5 hours. The duration will depend on the dosage and tolerance to the chemicals. People, who follow a healthy diet routine, don’t suffer from severe health effects.
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Chemical and physical data
Formula: C12H15NO3
Molar mass: 221.2524 g/mol g·mol?1
Pharmacokinetics
Analysis of human and rat urine for the metabolites of bk-amphetamines suggested that ethylone was degraded in the following metabolic steps:
N-deethylation to the primary amine.
Reduction of the keto moiety to the respective alcohol.
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As of October 2015 Ethylone is a controlled substance in China.
See also
5-Methylethylone
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Buy 4-MEC Powder (4-Methylethcathinone) is a chemical that bears a chemical resemblance to mephedrone. Due to its similarity to mephedrone, it is thought to be a stimulant and entactogen drug of the phenethylamine, amphetamine, and cathinone chemical classes. It has been marketed alone or in mixtures with other substituted cathinones under the name NRG-2, although other blends such as NRG-1” may have been more ambiguous with their ingredients.
4-MEC is reported to have been used as the active ingredient in fake “Ecstasy” pills in some countries such as New Zealand.
Recreational use
Some users have injected the drug intravenously. This requires heating the water/4-MEC solution in order for 4-MEC to dissolve. Injecting 4-MEC appears to be rough on veins and is sometimes accompanied by a burning sensation; for this reason 4-MEC should be diluted as much as possible. Intravenous dosages are comparable to oral ones, although more care should be given to safety (with regard to possibility of overdose and long-term effects).
Chemical and physical data
Formula: C12H17NO
Molar mass: 191.274 g·mol?1
Clinical data
Synonyms: 4-Methyl-N-ethylcathinone; 2-Ethylamino-1-p-tolylpropan-1-one
See also
4-Ethylmethcathinone
4-Methylbuphedrone
4-Methylcathinone
4-Methylpentedrone
Substituted cathinone
Benzedrone
Mephedrone
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Buy 3-CMC Crystal, (also known as 3-Chloromethcathinone and clophedrone) is a stimulant drug of the cathinone class that has been sold online as a designer drug, mainly in European countries such as Sweden, Italy and Poland. It is closely related in chemical structure to the antidepressant and anti-addictive medication bupropion, which is 3-chloro-N-(t-butyl)cathinone, though the pharmacological profile of 3-CMC is quite different.
Chemical and physical data
Formula: C10H12ClNO
Molar mass: 197.66 g·mol?1
Legality
As of October 2015 3-CMC is a controlled substance in China.
3-CMC and other cathinones are differentiated by their ketone substitution on the beta carbon of the amphetamine skeleton, meaning they are ?-keto-amphetamines. 3-CMC has two methyl substitutions on its cathinone skeleton, one at R3 of the phenyl ring, and a second at the nitrogen group RN. 3-CMC is analogous to mephedrone; it is identical in structure expect for the placement of the methyl group at R3 instead of R4.
3-CMC is sold for research purposes only and is not be utilized for any other purposes, including, but not limited to, in vivo diagnostic purposes, in foods, in drugs, in medicinal devices, and/or cosmetics for humans and/or animals.
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See also
3-Fluoromethcathinone
3-Fluoromethamphetamine
3-Methylmethcathinone
4-Chloromethcathinone
Substituted cathinone
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Buy Pentedrone Crystal Pentedrone (also known as ?-methylamino-valerophenone) is a stimulant of the cathinone class that has been sold as a designer drug and has been found since 2010 as an ingredient in a number of “bath salt” mixes sold as legal highs.
Pharmacology
Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor without causing their release, the same mechanism of action as methylphenidate.
Side effects
Pentedrone has been linked to at least one death where it was combined with ?-PVP and caused heart failure.
The chemical formula of Pentedrone indicated that the effects of this chemical compound might be very similar of mephedrone – the most famous cathinone research chemical synthesized during the last century.
Its pharmacology can provide strong binding to noradrenalin, dopamine and serotonin transporters, which could potentially be used as a potential anti-depressant like Ephedrone in 1940s was used in the Soviet Union. Further it give the chemical compound Pentedrone the possibility to be used in medical trials as a weight loss supplement – because it might have also a similar way of action like the synthetic cathinone amfepramone.
Detection
A forensic standard of Pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.
Legal status
On January 28, 2014, the DEA listed it, along with 9 other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.
Pentedrone is a Anlage II controlled drug in Germany.
As of October 2015 Pentedrone is a controlled substance in China.
Pentedrone is banned in the Czech Republic.
Chemical and physical data
Formula: C12H17NO
Molar mass: 191.269 g/mol g·mol?1
See also
4-Methylpentedrone
Buphedrone
MDPV
Methcathinone
Pentylone
Substituted cathinone
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?-PVP is banned in Estonia, Finland, France, Germany, Hungary, Ireland, Latvia, Lithuania, Poland, Romania, Slovenia, Sweden, United Kingdom, Turkey, Norway, as well as the Czech Republic.
Chemical and physical data
Formula: C15H21NO
Molar mass: 231.339 g·mol?1
Clinical data
Routes of administration: oral, intranasal, vaporization, intravenous, rectal, sublingual
See also
?-Pyrrolidinohexiophenone (?-PHP)
?-Pyrrolidinopentiothiophenone (?-PVT)
4?-Methoxy-?-Pyrrolidinopentiophenone
Naphyrone (O-2482)
Pentedrone
Pentylone
Prolintane
Pyrovalerone (O-2371)
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It was patented in 1972 and approved for medical use in 1983.
Pharmacology
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Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam possesses potent hypnotic properties, and is comparable with other short-acting benzodiazepines. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.
According to the Italian P.I. sheet, etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers, etizolam showed some similar characteristics to tricyclic antidepressants.
Interactions
Itraconazole and fluvoxamine slow down the rate of elimination of etizolam, leading to accumulation of etizolam, therefore increasing its pharmacological effects.Carbamazepine speeds up the metabolism of etizolam, resulting in reduced pharmacological effects.
Overdose
Cases of intentional suicide by overdose using etizolam in combination with GABA agonists have been reported. Although etizolam has a lower LD50 than certain benzodiazepines, the LD50 is still far beyond the prescribed or recommended dose. Flumazenil, a GABA antagonist agent used to reverse benzodiazepine overdoses, inhibits the effect of etizolam as well as classical benzodiazepines such as diazepam and chlordiazepoxide.
Etizolam overdose deaths are rising – for instance, the National Records of Scotland report on drug-related deaths, implicated 548 deaths from ‘street’ Etizolam in 2018, almost double the number from 2017 (299) and only six years from the first recorded death (in 2012). The 548 deaths were 45% of all drug-related deaths in Scotland in 2018.
Misuse
Etizolam is a drug of potential misuse. Cases of etizolam dependence have been documented in the medical literature. However, conflicting reports from the World Health Organization, made public in 1991, dispute the misuse claims. Since 1991, cases of etizolam misuse and addiction have substantially increased, due to varying levels of accessibility and cultural popularity.
Chemical and physical data
Formula: C17H15ClN4S
Molar mass: 342.07 g/mol g·mol?1
See also
Alprazolam
Brotizolam
Clotiazepam
Deschloroetizolam
Metizolam
Benzodiazepine dependence
Benzodiazepine withdrawal syndrome
Long-term effects of benzodiazepines
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BUY NITRACAINE CRYSTAL is a stimulant with local anesthetic properties that has been sold online as a designer drug. It is closely related to dimethocaine.
Description
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Nitracaine Crystal is known to have low solubility. This could potentially lead to a low permeation through tissues. Nitracaine may be utilised by researchers who wish to use it as a reference sample for their GC/MS, FTIR or NMR analysis catalogues.
Chemical and physical data
Formula C16H24N2O4
Molar mass 308.378 g·mol?1
3D model (JSmol)
Interactive image
Technical Information
Formal Name: 3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate
CAS Number: 1648893-21-3Molecular Formula: C16H24N2O4Formula Weight: 308.4Purity: ?98%Formulation: A crystalline solid?max: 259 nmSMILES: CC(CN(CC)CC)(C)COC(C1=CC=C([N+]([O-])=O)C=C1)=OInChi CodeInChI=1S/C16H24N2O4/c1-5-17(6-2)11-16(3,4)12-22-15(19)13-7-9-14(10-8-13)18(20)21/h7-10H,5-6,11-12H2,1-4H3
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Bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purpose.
bk-MDDMA (hydrochloride) is also a potential psychoactive mind-altering drug of the phenethylamine, amphetamine, and cathinone chemical categories. It’s structurally associated with methylone, a psychoactive drug that has been detected in product marketed as bath salts, plant food, and tablets. Dimethylone is meant for forensic functions.Buy Dimethylone Online
Formal Name 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)-1-propanone, monohydrochloride
CAS Number: 109367-07-9
Synonyms: Dimethylone
Molecular Formula: C12H15NO3 • HCl
Formula Weight 257.7
Purity ?98%
Formulation: A crystalline solid
?max: 235, 282, 320 nm
SMILES CC(N(C)C)C(C1=CC(OCO2)=C2C=C1)=O.Cl
InChI Code InChI=1S/C12H15NO3.ClH/c1-8(13(2)3)12(14)9-4-5-10-11(6-9)16-7-15-10;/h4-6,8H,7H2,1-3H3;1H
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Dimethylone is a research chemical which has significantly gained in popularity lately. The product is often sold as MDMA or bk-MDMA as well.The effects are however not the same, as Dimethylone belongs to the cathinone, amphetamine, and phenethylamine chemical classes. Dimethylone is colorless on its own but takes the appearance of a white powder after being crushed. Dimethylone has a stimulating effect similar to cocaine, although this transitions to the effect of amphetamine after 1-2 hours.
Dimethylone bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purposes.
Dimethylone bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purposes.
Dimethylone bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purposes.
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Buy 3,4-DMMC Powder
Buy 3,4-DMMC Powder also call 3,4-Dimethylmethcathinone is a stimulant drug first reported in 2010 as a designer drug analogue of mephedrone, apparently produced in response to the banning of mephedrone, following its widespread abuse in many countries in Europe and around the world. 3,4-DMMC has been seized as a designer drug in Australia.
3,4-Dimethylmethcathinone (hydrochloride) is a potential designer drug with combined features of amphetamines, cathinones, and phenethylamines. It is structurally related to 4-methylmethcathinone (4-MMC), a psychoactive compound that has been identified in products sold as bath salts and plant food. The physiological and toxicological properties of this compound have not been elucidated. This product is intended for research and forensic applications.
We supply high grade research chemicals. Our chemicals have a purity level of 99.5% and are all standardized for both research purposes and personal uses. We sell at very good and discount on bulk orders. Our research chemical products are very competitively priced because we benefit from direct access to a manufacturing facility.
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Legal Status
As of October 2015 3,4-DMMC is a controlled substance in China.
3,4-DMMC is banned in the Czech Republic.
Chemical and physical data
Formula: C12H17NO
Molar mass: 191.269 g/mol g·mol?1
See also
Substituted cathinone
Indanylaminopropane
Methylone
Xylopropamine
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Buy Methoxetamine Crystal
Buy Methoxetamine Crystal, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed for grey market distribution.
MXE is an arylcyclohexylamine. It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.
Recreational use
MXE is reported to have a similar effect to ketamine. It was often believed to possess opioid properties due to its structural similarity to 3-HO-PCP, but this assumption is not supported by data, which shows insignificant affinity for the ?-opioid receptor by the compound. Recreational use of MXE has been associated with hospitalizations from high and/or combined consumption in the US and UK. Acute reversible cerebellar toxicity has been documented in three cases of hospital admission due to MXE overdose, lasting for between one and four days after exposure.
MXE was designed in part in an attempt to avoid the urotoxicity associated with ketamine abuse; it was thought the compound’s increased potency and reduced dose would limit the accumulation of urotoxic metabolites in the bladder. Like ketamine, MXE has been found to produce bladder inflammation and fibrosis after high dose, chronic administration in mice (although the dosages used were quite large). Reports of urotoxicity in humans have yet to appear in the medical literature.
Pharmacokinetics
MXE has a longer duration of action than that of ketamine.
Detection in body fluids
A forensic standard of MXE is available, and the compound has been posted on the Forendex website of potential drugs of abuse.
Chemical and physical data
Formula: C15H21NO2
Molar mass: 247.33 g/mol g·mol?1
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Buy AM-2201 crystal
Buy AM-2201 crystal AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor. It is part of the AM series of cannabinoids discovered by Alexandros Makriyannis at Northeastern University.
AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2. The 4-methyl functional analog MAM-2201 probably has similar affinities. AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors. AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.
Product Description
AM2201 (Item No. 10707) is an analytical reference material characterized as a synthetic cannabinoid.
AM2201 is regulated as a Schedule I compound in the United States.
Abstract
Novel synthetic cannabinoids are appearing in recreational drug markets worldwide. Pharmacological characterization of these new drugs is needed to inform clinicians, toxicologists, and policy makers who monitor public health. [1-(5-Fluoropentyl)-1H-indol-3-yl](1-naphthyl)methanone (AM-2201) is an abused synthetic cannabinoid that was initially created as a research tool for investigating the endocannabinoid system.
Here we measured the pharmacodynamic effects of AM-2201 in rats, and simultaneously determined plasma pharmacokinetics for the parent drug and its metabolites. Male Sprague-Dawley rats were fitted with surgically implanted temperature transponders and indwelling jugular catheters under pentobarbital anesthesia. One week later, rats received subcutaneous injection of AM-2201 (0.1, 0.3, and 1.0 mg/kg) or its vehicle, and serial blood specimens were withdrawn via catheters. Core temperatures and catalepsy were measured just prior to each blood withdrawal, and plasma was assayed for drug and metabolites using liquid chromatography-tandem mass spectrometry.
Two new types of synthetic cannabinoids, an AM-2201 benzimidazole analog (FUBIMINA, 1) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM, 2), and three newly emerged phenethylamine derivatives, 25B-NBOMe (3), 2C-N-NBOMe (4), and a 25H-NBOMe 3,4,5-trimethoxybenzyl analog (5), were detected in illegal products distributed in Japan.
The identification was based on liquid chromatography–mass spectrometry (LC–MS) and gas chromatography–mass spectrometry (GC–MS), high-resolution MS, and nuclear magnetic resonance analyses. Different from the representative synthetic cannabinoids, such as JWH-018, which have a naphthoylindole moiety, compounds 1 and 2 were completely new.
Precautions
All of Croweed Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to Croweed that you will properly test and use any Products purchased from Croweed in accordance with industry standards. Croweed and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. Croweed reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to Croweed within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Technical Information
Formal Name: [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number: 335161-24-5
Molecular Formula: C24H22FNO
Formula Weight: 359.4
Purity: ?98%
Formulation: A neat solid
?max: 218, 247, 315 nm
SMILES: O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(CCCCCF)C4=CC=CC=C43
InChi Code: InChI=1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2
See also
AM-694
AM-1235
AM-2232
AM-2233
JWH-018
SDB-005
THJ-018
THJ-2201
MEPIRAPIM
NM-2201
Shipping & Storage Information
Storage: -20°C
Stability: ? 3 years
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