"There is a real risk that your present assets will become rapidly “stranded” by changes to global policies. This issue is thought to be serious enough by Mark Carney to warrant an on-going investigation by the Bank of England. I cannot begin to imagine what would happen to biomedical science in this country, and also abroad, if the Wellcome Trust’s budget were to shrink substantially. Please, please do not take that chance."Ariel Blocker, reader in microbiology and Wellcome Trust investigator, University of Bristol UKProfessor Farrar, director and board members of the Wellcome Trust