I tried some of them, and they are not helpful on the Lepton2.0, b/c the hardware revision simply does not support them. They will be implemented with the next HW revision that does add all the calibration stuff then.
For example, all the RBFO registers (which should deliver the Planck constants for flux to temp conversion) only deliver the standard values, which are R: 395653, B: 1428000, F: 1000 & O: 156000.
You can go ahead and enable radiometry mode with register 0x25 for SET and check it with 0x24 for READ, the raw values will change their offset then. This should compensate the ambient temperature (see section 8.4.2 of the datasheet), but it's not very accurate. I find myself more comfortable using an external temperature sensor and comparing those value with RAW value 8192 to calculate an offset (figure 10 of section 8.4.2: 8192 corresponds to the ambient/camera temp).
RAD_GLOBAL_GAIN & RAD_GLOBAL_OFFSET deliver changing values when radiometry mode is enabled. I suspected the gain value would be Planck constant R2 and the offset would be O, so I spent some time to put that into the conversion formula. But it's not making any sense, so I stopped there.