As of FF4, there's a hotkey conflict with FF's native hotkeys:
ctrl+shift+K is now bound to the web console - How we handle this conflict is questionable, but I personally would prefer to use the FB console over the built-in. When I need to use the console, I often also use the other features of FB. Would it be possible for FB to override the built-in hotkeys? Customizing the FF hotkeys is surprisingly complex and not something most users will be comfortable doing, so it would be best if the default configuration did not result in the FB hotkey being overridden as is currently the case.