Hi Nick,
The best answer I can give you is that I am not sure.
I can only encourage you to give it a try (would probably be a good idea to have debug logging enabled from the start) and see what happens.
There are two issues that might prove to be a problem: the first is that .NET ActiveX objects might not work properly with this plugin, and the second is the handling of Javascript objects - I don't think it'll be treated as an IDispatch object.
If you do decide to try it, I'd love to hear about the results.
Leeor.