The size of the domain "only" leads to high computing times, so it is
better to start getting some experience studying small cases first.
Then check yourself the effect of changing grid size or using multiple
meshes on such cases.
A good way is to learn from someone already skilled in using FDS.
Remember that FDS will not tell you "you are making wrong choices to
model your case".
So please be extremely careful if your results will be used to design
the fire safety of a real building.
In this case, check your results by making comparison with other
calculations as much as possible (zone models, hand calculation, etc.)
Good luck