Input data for fsc

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Shailesh Kumar Dhudabhai Desai

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Jan 15, 2026, 11:50:05 AMJan 15
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Dear Dr. Laurent and fsc community, 

I am bit new to fsc and after browsing the google group, i have some query if anyone can help !

My goal is to estimate various parameter like split and population size, and i have mutation rate.
i have two type of data, type 1 is having ony snp sites, and second data is whole genome, 
I understand that using only snp data without prior, i can not estimate split time, as there is no accurate monomorphic sites in data, and hence i have to use -0, to ignore monomorphic sites, which also by default ignore mutation rate. 

in second data, i have everything, but as fsc assume sites are unlinked, and if do pruning of data (remove high LD sites), then i might lose many SNps and monomorphic sites, so how to deal in this, i am confused. 
i am using eastSFS to compute the SFS data. 

I look forward for any help. 
Many thanks in advance. 

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