Which product are you planning on using exactly? (link?)
The NeoMatrix I found is 64 pixels, so you could drive 8 of them with one fadecandy, no problem.
The OpenPixelControl server does allow some configuration as to the layout of the pixel matrix, so you can map them in a way that makes sense for your application.
Note that if you want to control the RGBW NeoMatrixes, that's a bit more involved, and you can only drive 48 pixels with each output. If you can break the chain of leds and patch the next FC output to the 49th pixel, it would be doable to control that tho.