Hi,
No, assuming you're using "standard" SQL queries and nothing that is dependable on DB engine X or Y, then all you need to change is the connection string.
So, if using MySQL, use:
$db=new \DB\SQL('mysql:host=localhost;port=3306;dbname=mysqldb','username','password');
And if using SQLite, use:
$db=new \DB\SQL('sqlite:/path/to/db.sqlite');
And then just run your SQL queries or mapper functions as usual, e.g.:
$rows=$db->exec('SELECT id,name FROM mytable ORDER BY id DESC');
OR:
$user=new DB\SQL\Mapper($db,'users');
// or $user=new DB\Mongo\Mapper($db,'users');
// or $user=new DB\Jig\Mapper($db,'users');
$user->userID='jane';
$user->password=md5('secret');
$user->visits=0;
$user->save();
A lot more info about SQL database usage on F3 at:
Cheers