I've not started a build for Vista/IIS7 yet, but it's on my work list.
I suspect there are some issues w/ mapping the custom handler, but most of the other details should work fine. For example, I use a stand-alone version of the Utilities class on Vista quite regularly.
If you are working through it now, feel free to post your efforts here.
I'd be happy to work with you as you work out the details.
I am in the middle of a couple big projects and plan on tackling a Vista-compatible version this fall.
Looking forward to your feedback and suggestions.