haha... no wonder I wasn't sure what you meant. I didn't realize you were referring to extmodem.
My head has been focused on AVRs for the last weeks so no wonder I make weird assumptions.
It's point to point, but there isn't any handshaking or identity checks going on so all the computers running the program with radios should be able to decode the packages that they get.
In other words, if you set up three computers or more, with radios, and PC A transmits, then PC B and PC C would be able to receive the packages. As long as they are all working on the same frequency (for aprs in europe that'd be 144.8MHz).
I haven't really tested Santos' extmodem but I assume it works in a similar manner as most soundmodems for APRS or ax.25 (Note, I assume, as it's aprs compatible that it's not fully an ax.25 modem, as the APRS drops alot of functions that were in the old AX.25 protocol.)
Note: I haven't really tested this program, but I'll hook it up later today and see how it works if I have the spare time.
But you'd need another application to deal with the messaging and to create APRS packages, location reports and telemetry.
Like AGWPE or SarTrack or some other TNC capable APRS programs.
extmodem (afaik) only acts as a software TNC I think, (preparing the packages and encoding/decoding, setting the TX delay and such)
if the VOX on the radios you're using is a quality one, then I don't see any reason for it not to work. Might have to bring the TX delay a bit up. (TX Delay basically just adds "empty" packages in front of the real packages to make sure the transmitter is already sending, when the package goes to it up)
What kind of data are you trying to send out? normal APRS location packages? Messages or something else?
I hope this helps something, and sorry for the misunderstanding. :)