Calculator In Japanese

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Geralyn

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Aug 4, 2024, 2:01:59 PM8/4/24
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Purpose: To create a gonadotropin starting dose calculator for controlled ovarian stimulation, which can adjust the target number of oocytes and stimulation duration for each facility to achieve individualized controlled ovarian stimulation among the Japanese patients.


Methods: The patients received controlled ovarian stimulation using the gonadotropin-releasing hormone antagonist protocol, and oocytes were retrieved. Using single regression analysis, we selected age, anti-Mllerian hormone (AMH), and initial serum follicle-stimulating hormone as variables to predict the number of oocytes retrieved per gonadotropin dose (oocyte sensitivity index). Each variable was then analyzed using backward stepwise multiple regression.


Results: Age and AMH were selected as predictive variables from the backward stepwise multiple regression, and we developed a multiple regression equation. We decomposed the equation as the number of oocytes retrieved/(gonadotropin starting dose stimulation duration days) and created a calculation formula to predict the gonadotropin starting dose from the target number of oocytes and stimulation duration days.


Conclusions: This is the first study to develop an individualized dosing algorithm for gonadotropins among Japanese patients. Our calculator will improve controlled ovarian stimulation performance and enable national standardization by allowing all physicians, regardless of their years of experience, to determine the appropriate starting dose of gonadotropins equally.


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In the 1960s the first electronic integrated circuits were developed and manufactured in the U.S.A.. Although the early chips incorporated just a few transistors and other components, due to the reduction in the size of the circuit boards required they immediately saw use in hardware for the military and the "space race" with the U.S.S.R. Chips were also developed for use in the mainframe computers of the time where they gave increased functionality, together with the reduced size and cost.


One of the first consumer products to make use of integrated circuits was the electronic calculator. Indeed, during the late 1960s and early 1970s the development of electronics for calculators was at the forefront of technology and was often mentioned in electronics journals, and even in daily newspapers. The world was astounded in 1971 and 1972 when the first pocket electronic calculators became available in the shops and enabled everyone to carry a means to instant answers to their mathematical needs.


The pocket electronic calculator was also the first instance of a new phenomenon in the world of electronics; that of a product, previously unknown to the public, moving through its now familiar life cycle:


In the years from 1970 to 1975 electronic pocket calculators went through this cycle, which had brought instant calculating power to the general public for the first time, but it had a drastic effect on many of the manufacturers who in the early days thought that these devices were the route to large profits. Since those years, other electronic devices have followed this cycle, including video cassette recorders, personal stereos, and mobile telephones. Being aware of this cycle, manufacturers now know that they have a lot of hard work in front of them to be still making a profit at the end of the cycle.

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