I presume you have the latest service packs and updates installed,
both for the OS and SP 1 for Visual Studio 2010?
It sounds like it's only a problem when you're debugging.
What about installing a virtual machine with 32-bit XP just for the
debugging?
Are you up to exploring the freeze with the kernel debugger? I'm
guessing it is essentially hitting some type of breakpoint in Excel,
and not dealing with the debugger attach correctly.
I trust you'll forgive me if I don't plan to look for a 64-bit version
XP to try this myself ;-)
-Govert