Govert's right (as usual).
You need to
1. Add a project reference to the "Microsoft Excel 15.0 Object Library" (or 14.0, etc) library.
2. Import the Microsoft.Office.Interop.Excel namespace.
3. Get an object reference to an instance of Excel in your program, from the type Microsoft.Office.Interop.Excel. (Make sure to specify the namespace to avoid conflicts with System.Windows.Forms.Application.)
It's handy to keep a static Application instance somewhere accessible, like Program.cs, and reference that throughout the program.
You can launch a new Excel instance using the Application constructor:
public static Microsoft.Office.Interop.Excel.Application app = new Microsoft.Office.Interop.Excel.Application();
You can get a reference to an existing Excel instance with System.Diagnostics.Process. (Although it can be tricky in some situations.) Like this:
Process xlProcess = Process.GetProcessesByName("EXCEL")[0];
The Process method can have issues in situations with multiple instances of Excel, multiple users with instances of Excel, or restricted security permissions.