Oh, I understood your question as "can I use interop?" ... you can.
You have a few other options, but they require a bit more work:
(1) You can use whatever writeback support is provided by the XLL interface. What do you need to do? Write formulas and values to cell?
(2) You can use netoffice, which provides simple wrapper classes around interop objects. It used reflection to poke in values.
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