Folding rbcL (the large subunit of Rubisco)
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mane...@gmail.com
Feb 26, 2016, 8:32:15 AM2/26/16
to EVCouplings
Hello,
Did somebody try to fold rbcL with EVCouplings? Rubisco is a highly conserved enzyme (sequence and 3D structure) fixing atmospheric carbon during photosynthesis in photosynthetic bacteria and plant chloroplasts. It is a hexadecamer of 8 L (large) and 8 S (small) subunits. I am more interested in detecting of coevolving residues in the large subunit encoded by rbcL. Studies based on CAPS and CoMap show that detected coevolving sites are distantly located on the 3D structure and consequently EVCouplings fails to find the true 3D structure.
Any help?
Jean-Francois Manen
Did somebody try to fold rbcL with EVCouplings? Rubisco is a highly conserved enzyme (sequence and 3D structure) fixing atmospheric carbon during photosynthesis in photosynthetic bacteria and plant chloroplasts. It is a hexadecamer of 8 L (large) and 8 S (small) subunits. I am more interested in detecting of coevolving residues in the large subunit encoded by rbcL. Studies based on CAPS and CoMap show that detected coevolving sites are distantly located on the 3D structure and consequently EVCouplings fails to find the true 3D structure.
Any help?
Jean-Francois Manen
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