Hello everyone,
I just saw this FDA codeine use safety warning and I thought I would share since it's particularly relevant for Ethiopian population. Below is the link but here is a short summary:
What is it?
Safety announcement on the use of Codeine (pain reliever) in young children after tonsil removal (tonsillectomy).
What happened?
Reports of death or life threatening outcomes in children age 2-7 who have taken codeine after tonsil removal.
Why should Ethiopians care?
According to FDA report, Ethiopian population carry a much higher rate (29%) of a DNA mutation in a gene that codes for an enzyme that converts codeine to morphine compared to other populations eg. whites (~7%). This mutation makes the enzyme "super-active", hence individuals that carry this mutation convert codeine to morphine at a very fast rate ("ulta-rapid metabolizes"). Increased level of morphine in children results in respiratory depression. Since the "ultra-rapid metabolizes" frequency is high among Ethiopians, this might make Ethiopian kids more sensitive to codeine side effects after tonsil removal.
What should parents and caregivers do?
Don't panic! Be informed, talk to your doctor and pay attention to side effects
- Signs of serious side effects of codeine in children can include unusual sleepiness, confusion, and difficult or noisy breathing. If your child shows these signs, stop giving your child codeine and seek medical attention immediately by taking your child to the emergency room or calling 911.
Read the link below for the full report.
Have a wonderful Holiday season.
Best,
Measho