trasplante pancreas
jqu...@mundo-r.com
de páncreas, así como de sus resultados a corto y medio plazo.
Maax Headroom
1: J Hepatobiliary Pancreat Surg. 2008 Dec 26. [Epub ahead of print]
LinksIslet cell transplantation for the treatment of type 1 diabetes in the
USA.Ikemoto T, Noguchi H, Shimoda M, Naziruddin B, Jackson A, Tamura Y,
Fujita Y, Onaca N, Levy MF, Matsumoto S.
Baylor Research Institute, Baylor Institute for Immunology Research, Dallas,
TX, USA.
Islet cell transplantation (ICTx) is one of the most effective treatments
for type 1 diabetes and is less invasive compared to whole organ
transplantation. The US has been the leader in the research and clinical
applications of ICTx for the last 40 years. ICTx requires complex
procedures, including pancreas procurement and preservation; pancreas
digestion; islet purification; and transplantation. Even with the dramatic
progresses in each of the procedures listed above, there are still
challenges to make ICTx the standard therapy. These challenges are: (1)
obtaining enough islets from a single donor and (2) preventing graft loss
due to allogenic rejection and recurrence of autoimmune islet destruction. A
new preservation strategy for pancreata and pancreatic ducts using ET-Kyoto
solution as well as a new islet purification method using iodixanol has
substantially improved islet yields. Continuous research to improve the
efficacy of islet isolation will solve the issue of obtaining enough islets
from a single donor. Immunological tolerance is an ideal solution for the
issue of rejection and autoimmune recurrence and a regulatory T cell
strategy seems promising. Moreover, the SUITO index is a simple and powerful
tool to assess engrafted islet mass and is, therefore, useful for evaluating
the efficacy of new immunosuppressant strategies. Once ICTx becomes a
standard treatment, the donor shortage will become the next challenge.
Marginal or living donor islet transplantations could help alleviate this
issue; however, bio-artificial islet transplantation with animal islets
could be the ultimate solution.
--> Puedes empezar por aquí y seguir los vínculos a artículos referidos.
Estos de Baylor son de los mejores y está recién sacado del horno. Suerte.
<jqu...@mundo-r.com> escribió en el mensaje de
noticias:6290b469-4248-47d6...@g3g2000pre.googlegroups.com...
> me gustaría recibir información sobre las indicaciones del trasplante
> de páncreas, así como de sus resultados a corto y medio plazo.
>
>
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