Getting to our list of the best james patterson books is the gripping series of Alex Cross, Run. It still follows Detective Alex Cross as he faces one of the most dangerous adversaries of his career. Cross becomes involved in a web of deception and violence when someone brutally murders a beloved family member. So, he hunts down the killer and navigates the underbelly of Washington, D.C., encountering ruthless criminals and corrupt politicians. With time running out, Cross must use his unparalleled skills to solve the case and bring the killer to justice.