DNA origami that fits into a PDMS socket?

[Nathan McCorkle]

If you could make a nanofluidic 'tunnel' out of DNA origami that when
washed over an open microfluidic channel, stuck into a certain cut-out
section and was sealed around the edges... I think you'd have a cheap
source of nanofluidic reaction centers for something like
single-molecule DNA synthesis, which maybe could be measured with
capacitance or UV Raman spectroscopy to feedback info about whether
extension occurred or not.

--
Nathan McCorkle
Rochester Institute of Technology
College of Science, Biotechnology/Bioinformatics

[Nathan McCorkle]

rOn Wednesday, February 29, 2012 12:36:37 AM UTC-5, Nathan McCorkle wrote:

If you could make a nanofluidic 'tunnel' out of DNA origami that when
washed over an open microfluidic channel, stuck into a certain cut-out
section and was sealed around the edges...

Note that I'm talking about using PDMS as the microfluidic channel, which is an elastomer so will have some flex to it. Maybe the cutout is a rectangle, and the DNA origami is cuboid shaped with the tunnel going through lengthwise... for that matter, maybe you make it a T shape, so you get specificity for the entrance of the tube.     

 

--
Nathan McCorkle
Rochester Institute of Technology
College of Science, Biotechnology/Bioinformatics