Philips Chan

[Tisa]

MrChan, who immigrated to Singapore over 30 years ago, has more than 20 years of experience in the property sector. He is concurrently the managing director of Wen Way Investments and Mutual Benefits Realty, as well as chief executive at C&H Properties.

In Singapore, Mr Chan is also president of the Hong Kong Singapore Business Association, which helps to link business communities in Singapore and Hong Kong, and promotes industry and commerce between both cities and China.

In his earlier interview with Chinese Headline New Media, Mr Chan said being overseas had exposed him to various voices about China, and added that China is often at a disadvantage in the war of public opinion.

He also said his hope is that after the Two Sessions meetings, overseas Chinese representatives from around the world can establish an alliance and organise a conference to facilitate exchanges and understanding.

In his interview, he also encouraged young people of all ethnicities to develop a deeper understanding of China, noting that many people who grew up overseas lack sufficient understanding of the country and its culture.

I think there have been many challenging situations during the COVID-19 pandemic. Some of the more difficult ones that we dealt with in public health included nursing homes, where deaths during outbreaks occurred in up to 30% of all residents. At the moment, the most challenging situation is addressing the significant amount of misinformation about COVID-19. It is deeply troubling that some people are basing their health decisions on such misinformation. We must place a greater emphasis on the science. People also need to realize that science evolves over time and that sometimes our understanding of an issue may change. However, you can be sure that the last place you should be getting information about your health is Facebook or TikTok.

Both public health and healthcare in general were stressed before the COVID-19 pandemic, and have been overwhelmed since then. I want to acknowledge all the hard work of my public health and healthcare colleagues. I think a major priority for the state should be to work to stabilize and build up our healthcare and public health infrastructure. There are also several other public health issues that deserve significant attention. Mental health and substance use have both been exacerbated by the COVID-19 pandemic. Hepatitis C (spread by blood contact) and sexually transmitted infections (STIs) continue to increase. There are ongoing initiatives and partnerships across Rhode Island to address these issues, which will require timely attention and resources to reverse increasing trends.

HIV and other STIs: People should also be tested at least once for HIV in their lifetime. Younger people may be at higher risk for STIs and should be tested if sexually active. For those who may be at higher risk of HIV, pre-exposure prophylaxis (PrEP) is a pill a day that people can take which prevents infection.

I want to thank Rhode Islanders for their patience and resilience during the COVID-19 pandemic. I think it is critical for all of us to work together in a productive way to address issues of public health concern. We should continue to base our decisions on science and evidence, and continue to perform research to answer unknown questions and address evolving questions. Above all, we should continue to show respect and kindness to those around us, even when we disagree!

Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.

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Neurovascular coupling reflects the close temporal and regional linkage between neural activity and cerebral blood flow. Although providing mechanistic insight, our understanding of neurovascular coupling is largely limited to non-physiologicalex vivopreparations and non-human models using sedatives/anesthetics with confounding cerebrovascular implications. Herein, with particular focus on humans, we review the present mechanistic understanding of neurovascular coupling and highlight current approaches to assess these responses and the application in health and disease. Moreover, we present new guidelines for standardizing the assessment of neurovascular coupling in humans. To improve the reliability of measurement and related interpretation, the utility of new automated software for neurovascular coupling is demonstrated, which provides the capacity for coalescing repetitive trials and time intervals into single contours and extracting numerous metrics (e.g., conductance and pulsatility, critical closing pressure, etc.) according to patterns of interest (e.g., peak/minimum response, time of response, etc.). This versatile software also permits the normalization of neurovascular coupling metrics to dynamic changes in arterial blood gases, potentially influencing the hyperemic response. It is hoped that these guidelines, combined with the newly developed and openly available software, will help to propel the understanding of neurovascular coupling in humans and also lead to improved clinical management of this critical physiological function.

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