Thevideo game Batman: Arkham Asylum takes place entirely in Arkham Asylum. The asylum is located on an island with a North, East and West courtyard. In the East courtyard, there is the Arkham Mansion, presumably a relic of the Arkham family where much of the staff works, as well as a Botanical garden, presumable for recreational uses. The North section contains the main entrance to Intensive Care and an unused, dilapidated structure. The West contains cell blocks, the Visitor Center and the Medical Facility. The asylum has a mainly gothic look, with many interior gargoyles, but has recently been outfitted with high-tech security, including forcefield security doors. There is also an on-site Batcave in the Caves. Many new staff members are introduced in the game. The security guards are heavily armed and armoured, resembling riot police, and, unlike traditional mental hospitals, the head administrator is a Warden named Quincy Sharp. Also introduced is Doctor Penelope Young and Guard Frank Boles. Many of these these characters are revealed to be corrupt. Boles aids the Joker in his takeover of Arkham, Young is studying clandestine research with Venom, and the Warden has followed in the insane footsteps of Amadeus Arkham, murdering inmates personally.
Amadeus Arkham originally founded the Elizabeth Arkham Asylum for the Criminally Insane after his mother, whom he euthanized as treatment for her dementia. Building it on the old grounds of his family's historic mansion on the outskirts of Gotham City, Amadeus personally treated it's first inmate--Martin "Mad Dog" Hawkins, who had killed Arkham's wife and daughter. After administering fatal electroshock therapy to Hawkins, Amadeus lost all grip on sanity and was admitted into his own institution.
Amadeus was a highly respected psychiatrist until his fall to insanity, and was heir to the Arkham land and fortune. In his last years locked away in a cell within his own mansion, Amadeus was diagnosed as being a delusional schizophrenic.
Quincy Sharp has been running Arkham Asylum for the past three years and has dedicated his life to restoring to sanity of the so-called super villains that plague Gotham City. He is currently campaigning to become the next mayor of Gotham; to facilitate the campaign, he has instigated stringent new security and experimental research policies at Arkham.
Sharp has an Intense dedication to "cleaning up" Arkham, and is pompous and old-fashioned in demeanor, with a focus on his own political aspirations. His contempt for Arkham inmates and disinterest in the specifics of their treatment masks a cowardly nature.
Arkham Asylum came under attack in Batman: Arkham Asylum. After numerous escapes by the Joker, the asylum worked more to ensure security, having every guard present as the Joker was returned to the island. The Joker escaped custody in the Intensive Treatment Center, causing chaos. He freed several Blackgate Convicts housed in the Holding Cells and caused untold damage to the facilities in his personal vendetta against Batman. Running amok through Arkham Asylum, Joker paused only briefly to murder or vandalize. Most of the security force was overwhelmed by the freed convicts, and later the more unsettled mental patients were loosed, rampaging through the asylum. More damage was caused as the Joker used asylum facilities to carry out his own evil experiments for the Titan Project, originally developed by Dr. Penelope Young. When the experimental drug was perfected, The Joker allowed some to be given to Poison Ivy, who overran the asylum with her plants. The heavily-damaged and partially demolished facility was recaptured as the Gotham City Police stormed the island, recapturing many of the escaped inmates after the Joker's defeat.
It was here the Joker was being transferred back to his cell. As the Joker was being escorted by a doctor and a security guard through the Holding Cells, he broke free and killed both men. Batman, watching from a reception area, crashed through a window in pursuit. The Joker loosed all the Blackgate convicts in the Holding Cells to attack Batman. He then made his way through the Processing Corridor, killing four security guards in the area.
Joker continued to the Decontamination Chamber while the remaining security personnel were preoccupied with trying to recapture Victor Zsasz, who had already murdered a guard in the Patient Pacification Chamber and was holding another hostage. After Batman had arrived on Joker's trail and subdued Zsasz, the Arkham staff retook control of the Patient Pacification Chamber. Meanwhile, the Joker had filled the Decontamination Chamber with toxic gas, killing escaped convicts and security guards alike, leaving only four survivors, who had managed to climb to safety. The Joker continued on to the Transfer Loop, killing more security staff and vandalizing everything with spray paint. He then proceeded to the Secure Treatment Transfer with several of his men, who overwhelmed the guards. The Joker loosed a mutated Blackgate prisoner on Batman, who died of natural causes after fighting the Dark Knight. The Joker escaped through Extreme Isolation, and the sole surviving security guard was not able to allow Batman through, due to the fact the Joker had rendered the computerized transport system to Extreme Isolation unusable. Around this time, corrupt security guard Frank Boles kidnapped James Gordon and took him through the Transfer Loop and into Secure Transit with Harley Quinn. Another security guard, Henry Smith, attempted to follow them, only to find that someone had jammed the elevator controls.
On the upper level, a team of the Joker's men had seized control of the elevator area, which had been further disabled by Harley Quinn in an effort to slow Batman down. Armed convicts, meanwhile, had wrestled control of the Cell Block Transfer section from the guards. With the situation spinning out of control, William North and a security team were still guarding the Intensive Treatment Lobby, oblivious as to the impending situation. Frank Boles betrayed them, killing at least three guards. An army of Blackgate prisoners finished off the rest of the guards while William North fled to the Utility Corridor. Batman arrived on the scene, shortly after, re-securing the area and finding Boles dead, betrayed himself by his employer, the Joker. Later, as Poison Ivy's plants began to overrun the island, the Blackgate prisoners returned and recaptured the Intensive Treatment Lobby. The Center by this point was becoming heavily damaged by Ivy's mutated plants. Batman returned to the Cell Block Transfer section, where the Scarecrow and an army of Blackgate prisoners ambushed him. Batman followed the Scarecrow back into Secure Transit and defeated the remaining henchmen. The Intensive Treatment Center was liberated by the GCPD as the police took control of Arkham island.
Shortly after the Joker had seized control of Intensive Treatment, security officer Louie Green and over a dozen guards were directed to Arkham East by the Joker, where their radios went dead. At least three security guards patrolled around the Arkham Mansion, and one was posted inside the Mansion Entrance Hall to prevent entrance.
However, shortly afterward, an army of escaped Blackgate convicts stormed Arkham East, armed with weapons stolen from the guard armory. The security guards posted around the mansion were overpowered and several killed. The convicts entered the Main Hall, murdering the lone guard and bypassing the security barrier. Three remained to guard the Mansion Entrance Hall, while many other convicts penetrated deeper into the mansion. Eager to find Dr. Penelope Young's formula for her Titan Project hidden in the mansion, the Joker ordered many of his men to scour the mansion for the formula. The disorganized facilities were stuffed full of scattered discarded documents, so the Joker's men were facing a hopeless situation in trying to find the paper with the formula. The convicts entered the reception area of the Main Hall, killing four members of security personnel who attempted to stop them. One convict entered the West Wing Corridor, capturing at least two Arkham employees. Batman arrived in the Arkham Mansion shortly after, defeating the three convicts in the Mansion Entrance Hall, the one in the West Wing Corridor, and the others in the Main Hall.
In the Records Room of the Arkham Mansion, six convicts intercepted Dr. Young along with two security guards, Zach Franklin and Aaron Cash. The two guards were taken hostage while Young escaped to her office. Batman arrived to free Cash and Franklin, while three convicts discovered Young's office and tried to break into it. Using the Ventilation System, Batman reached the North Corridor, where two cells were, one in which Amadaeus Arkham spent his last years. Meanwhile, many of the Joker's men had moved down the Southern Corridor, securing and the multi-level mansion Library. It was here Dr. Young fled, encountering an orderly and an unidentified member of security personnel, identified only as "Bill". Bill attempted to defend Young, but all three were inevitably captured. Batman, meanwhile, had managed to defeat the convicts breaking into Young's office and learned from the security moniters that Young had taken the formula from her office safe and fled. Batman rushed to the Southern Corridor and then to the Library, finding the Joker's men tearing the area apart in search of Young's formula. Young herself had been taken to the Joker, who decided to use Victor Zsasz to torture the formula out of her. On the lowest level of the Library, Batman discovered Bill and the orderly tied up in front in front of a bomb, later revealed to have been a fake. The Scarecrow, meanwhile, had proceeded to the mansion, rigging the Southern Corridor with his fear gas to entrap Batman. Wandering around in a drugged state, Batman awoke from an intense nightmare in the Arkham Mansion's bell tower. The Dark Knight cut the rope of the bell to send it crashing to the floor below, causing extensive damage to the mansion's East Wing Corridor. Zsasz was hiding in Warden Sharp's office, having tortured the formula out of Young. He used her as a hostage, but Batman used a batarang to knock him out. Young was killed by a booby-trap rigged in the Warden's safe while trying to retrieve the security codes. Harley Quinn took Sharp through the mansion afterward, beating Sharp brutally with his cane and leaving several convicts to "hurt" Batman. Quinn took Sharp out of the mansion, and Batman left the Arkham Mansion in pursuit. Shortly after, the Joker loosed the more unsettled mental patients of the island, who ravaged the mansion grounds but did not enter the mansion itself. The Arkham Mansion suffered extremely heavy damage when Poison Ivy's Titan-enhanced plants overran the island. Aaron Cash and Zach Franklin regrouped with doctor Kevin Liew and a third surviving security guard in the mansion's Main Hall. The mutant plants, however, smashed through the mansion's windows and killed the third, unidentified, guard. Batman returned to the Arkham Mansion shortly after, finding Cash and Franklin standing around the plants and Liew seated behind a desk. The Arkham Mansion's Entrance Hall was so overrun by Ivy's plants that the hall became filled with toxic spores released from the mutated vegetation, and Batman warned Cash to stay away from the plants as they would most likely kill him. The remains of the Arkham Mansion were retaken by the GCPD as they recaptured the island.
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