Hi Julius,
I'm sorry to hear about the problem.
The actual error message that you are seeing is likely "Unable to find an Eggbot on any serial port. :(" I, personally, don't think that this sounds anything like "you are screwed." If you would like to suggest a different phrasing, please do. Our intent is certainly not to anger you, nor to create the impression that the situation is hopeless. In the vast majority of cases where people see that message, it genuinely is because the USB cable is not plugged in.
That said, the situation that you are describing -- where the Eggbot hardware is working, but yet it cannot connect through Inkscape -- is rare. The most likely situation is that something "unusual" on your computer is blocking access to the serial port. That could be as simple as leaving a putty connection open, it could be anti-viral/malware software on your computer blocking ports, it could be other USB devices, especially ones that take special drivers. (We have seen cases where uncommon USB devices have caused conflicts.) Can you think of anything that might be causing an issue of that type?
We have also on occasion heard of intermittent problems due to USB cable or hub issues. These have sometimes presented as Eggbots that show up in the device manager, but can't connect from Inkscape, or which print for a while and then stop. If you have a different USB cable that you can try (or if you are using a hub or extension) you might try to see if anything makes a difference.
Windell H. Oskay, Ph.D.
Co-Founder and Chief Scientist
Evil Mad Scientist Laboratories
175 San Lazaro Ave, STE 150
Sunnyvale CA 94086
http://www.evilmadscientist.com/