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Virginie Fayad

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Jun 11, 2024, 3:45:15 AM6/11/24
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Background: In 2011, the median age of survival of patients with cystic fibrosis reported in the United States was 36.8 years, compared with 48.5 years in Canada. Direct comparison of survival estimates between national registries is challenging because of inherent differences in methodologies used, data processing techniques, and ascertainment bias.

Measurements: Cox proportional hazards models were used to compare survival between patients followed in the CCFR (n = 5941) and those in the CFFPR (n = 45 448). Multivariable models were used to adjust for factors known to be associated with survival.

Results: Median age of survival in patients with cystic fibrosis increased in both countries between 1990 and 2013; however, in 1995 and 2005, survival in Canada increased at a faster rate than in the United States (P < 0.001). On the basis of contemporary data from 2009 to 2013, the median age of survival in Canada was 10 years greater than in the United States (50.9 vs. 40.6 years, respectively). The adjusted risk for death was 34% lower in Canada than the United States (hazard ratio, 0.66 [95% CI, 0.54 to 0.81]). A greater proportion of patients in Canada received transplants (10.3% vs. 6.5%, respectively [standardized difference, 13.7]). Differences in survival between U.S. and Canadian patients varied according to U.S. patients' insurance status.

Conclusion: Differences in cystic fibrosis survival between Canada and the United States persisted after adjustment for risk factors associated with survival, except for private-insurance status among U.S. patients. Differential access to transplantation, increased posttransplant survival, and differences in health care systems may, in part, explain the Canadian survival advantage.

Background: The rate of survival after out-of-hospital cardiac arrest is low. It is not known whether this rate will increase if laypersons are trained to attempt defibrillation with the use of automated external defibrillators (AEDs).

Methods: We conducted a prospective, community-based, multicenter clinical trial in which we randomly assigned community units (e.g., shopping malls and apartment complexes) to a structured and monitored emergency-response system involving lay volunteers trained in cardiopulmonary resuscitation (CPR) alone or in CPR and the use of AEDs. The primary outcome was survival to hospital discharge.

Results: More than 19,000 volunteer responders from 993 community units in 24 North American regions participated. The two study groups had similar unit and volunteer characteristics. Patients with treated out-of-hospital cardiac arrest in the two groups were similar in age (mean, 69.8 years), proportion of men (67 percent), rate of cardiac arrest in a public location (70 percent), and rate of witnessed cardiac arrest (72 percent). No inappropriate shocks were delivered. There were more survivors to hospital discharge in the units assigned to have volunteers trained in CPR plus the use of AEDs (30 survivors among 128 arrests) than there were in the units assigned to have volunteers trained only in CPR (15 among 107; P=0.03; relative risk, 2.0; 95 percent confidence interval, 1.07 to 3.77); there were only 2 survivors in residential complexes. Functional status at hospital discharge did not differ between the two groups.

Conclusions: Training and equipping volunteers to attempt early defibrillation within a structured response system can increase the number of survivors to hospital discharge after out-of-hospital cardiac arrest in public locations. Trained laypersons can use AEDs safely and effectively.

Survival or survivorship, the act of surviving, is the propensity of something to continue existing, particularly when this is done despite conditions that might kill or destroy it. The concept can be applied to humans and other living things (or, hypothetically, any sentient being), to physical object, and to abstract things such as beliefs or ideas. Living things generally have a self-preservation instinct to survive, while objects intended for use in harsh conditions are designed for survivability.

Historical references to survival cover aspects ranging from individual survival to that of empires, civilization,[3] and of the human race as a whole. The concept is also applied to non-living and non-physical things. In engineering, the term can be used to mean "the continued ability of the system to perform the desired function".[4] In law, it often refers to a holder of a legal interest who outlives another with whom that interest is shared, such as a surviving spouse, or to the interest itself, such as a right of survivorship.[5] In the United States, a designated survivor is a named individual in the presidential line of succession, chosen to stay at an undisclosed secure location, away from events such as State of the Union addresses and presidential inaugurations, to prevent a hypothetical decapitation of the government and to safeguard continuity in the office of the president in the event the president along with the vice president and multiple other officials in the presidential line of succession die in a mass-casualty incident.[6] Congress also designates members of the Senate and House, one from each party to become their own "designated survivor" to maintain the existence of Congress in the event of a mass-casualty event.[7]

In much of the literature on life after death, the term survival is employed more or less interchangeably with the term immortality. And yet it is not difficult to see why the term immortality is often preferred, particularly in some religious circles. It is not simply that it is free of the associations the term survival has with merely 'living on', or with lucky escape. More positively, the term immortality suggests some superior quality of existence, whereas the term survival suggests mere temporal extension, a continuation of the status quo ante.[8]

Survival analysis is a branch of statistics for analyzing the expected duration of time until one or more survival-ending events happen, such as death in biological organisms and failure in mechanical systems.[9] One element of survival analysis is the survival rate, the percentage of people in a study or treatment group still alive for a given period of time after diagnosis. It is a method of describing prognosis in certain disease conditions. Survival rate can be used as yardstick for the assessment of standards of therapy. The survival period is usually reckoned from date of diagnosis or start of treatment. Survival rates are important for prognosis, but because the rate is based on the population as a whole, an individual prognosis may be different depending on newer treatments since the last statistical analysis as well as the overall general health of the patient.[10]

Individuals who are concerned with surviving an anticipated catastrophic or apocalyptic event are often grouped within the practice of survivalism. Use of the term survivalist in this sense dates from the early 1960s.[11]

There are various kinds of media about survival. In both fiction and nonfiction, stories about individuals surviving despite particularly dangerous circumstances are popular. There is also a wide body of educational literature, sometimes referred to as a survival guide, offering advice on survival skills in various dangerous situations such as getting lost without food or water, being attacked, or being in a natural disaster.

In film, the survival film is a genre in which one or more characters make an effort at physical survival, generally while being subject to hazardous conditions or a catastrophic event. It often overlaps with other film genres. It is a subgenre of the adventure film, along with swashbuckler films, war films, and safari films.[12] Survival films are darker than most other adventure films, which usually focus their storyline on a single character, usually the protagonist. The films tend to be "located primarily in a contemporary context" and so film audiences are familiar with the setting, and the characters' activities are less romanticized.[13] In a 1988 book, Thomas Sobchack compared the survival film to romance: "They both emphasize the heroic triumph over obstacles which threaten social order and the reaffirmation of predominant social values such as fair play and respect for merit and cooperation".[13] The author said survival films "identify and isolate a microcosm of society", such as the surviving group from the plane crash in The Flight of the Phoenix (1965) or those on the overturned ocean liner in The Poseidon Adventure (1972). Sobchack explained, "Most of the time in a survival film is spent depicting the process whereby the group, cut off from the securities and certainties of the ordinary support networks of civilized life, forms itself into a functioning, effective unit". The group often varies in types of characters, sometimes to the point of caricature. While women have historically been stereotyped in such films, they "often play a decisive role in the success or failure of the group".[14]

In video games, the survival game, is a subgenre of action video games set in hostile, intense, open-world environments. Players generally begin with minimal equipment and are required to survive as long as possible by crafting tools, weapons, shelters, and collecting resources.[15][16] These can take the form of survival horror games, which focus on survival of the character as the game tries to frighten players with either horror graphics or scary ambience. Although combat can be part of the gameplay, the player is made to feel less in control than in typical action games through limited ammunition or weapons, health, speed and vision, or through various obstructions of the player's interaction with the game mechanics.

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