Image Processing with MATLAB: Applications in Medicine and Biology explains complex, theory-laden topics in image processing through examples and MATLAB algorithms. It describes classical as well emerging areas in image processing and analysis.
Providing many unique MATLAB codes and functions throughout, the book covers the theory of probability and statistics, two-dimensional fast Fourier transform, nonlinear diffusion filtering, and partial differential equation (PDE)-based image denoising techniques. It presents intensity-based image segmentation methods, including thresholding techniques as well as K-means and fuzzy C-means clustering techniques. The authors also explore Markov random field (MRF)-based image segmentation, boundary and curvature analysis methods, and parametric and geometric deformable models. The final chapters focus on three specific applications of image processing and analysis.
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Medical Imaging Systems
Fundamental Tools for Image Processing and Analysis
Probability Theory for Stochastic Modeling of Images
Two-Dimensional Fourier Transform
Nonlinear Diffusion Filtering
Intensity-Based Image Segmentation
Image Segmentation by Markov Random Field Modeling
Deformable Models
Image Analysis
Application 1: Quantification of Green Fluorescent Protein eXpression in Live Cells: ProXcell
Application 2: Calculation of Performance Parameters of Gamma Cameras and SPECT Systems
Application 3: Analysis of Islet Cells Using Automated Color Image Analysis
Written for undergraduate and graduate students, researchers, and medical physicists, this book helps readers understand advanced concepts in image processing such as Markov random field modeling by providing algorithms and by demonstrating their application on real-world problems in medicine and biology. The book provides extensive coverage of the fundamental tools in image processing and analysis, such as numerical derivatives, image simulation, processing, and manipulation of 3D images, demonstrated with MATLAB code.
BIOEN 290 Guided Independent Studies on Transformative Science (4) NSc
Intensive laboratory experience mixed with lectures, readings, and discussions aimed at achieving deep understanding of scientific approach, particularly the nature of paradigm shifts, role of governmental support and management of science, power of orthodoxy, role of challenger, and fate of unpopular scientific views. Offered: W.
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BIOEN 335 Biotransport II (3)
Studies the principles of combined mass transport in homogeneous and heterogeneous reaction systems as applied to biological processes. Introduces chemical and biochemical reaction kinetics, methods of evaluating kinetic parameters for reaction rate data, and prediction of the performance of biological and biochemical processes. Prerequisite: minimum grade of 2.0 in BIOEN 325. Offered: W.
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BIOEN 407 Bioengineering Nepal: Technology Assessment for Community and Global Health (5) NSc, DIV
Study abroad course that explores healthcare challenges faced globally in low-resource settings by studying clinical practice in Nepal. Students investigate healthcare delivery in a community hospital and a rural clinic, then evaluate clinical needs from holistic economic, social, and technological perspectives. Includes written analysis and public presentation of findings. Integrated with the Bioengineering Nepal Study Abroad program. Recommended: either G H 101/GEOG 180/JSIS B 180, G H 201, or BIOEN 215. Offered: jointly with G H 407; A.
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BIOEN 436 Quantitative Physiology (3)
Develops a foundation of human physiology by examining the homeostasis of vital parameters within the body, and the physiological properties of human cells, tissue, and organs. Recommended: MATH 207 or AMATH 351; courses in ordinary differential equations; probability theory; introductory programming; and introductory cell and molecular biology.
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BIOEN 440 Introduction to Biomechanics (4)
Presents the mechanical behavior of tissues in the body and the application to design of prostheses. Tissues studies include bone, skin, fascia, ligaments, tendons, heart valves, and blood vessels. Discussion of the structure of these tissues and their mechanical response to different loading configurations. An important part of the class is a final project. Offered: jointly with M E 445; Sp.
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BIOEN 454 Bioengineering Solutions to Improve the Health of Families Worldwide (1) SSc, DIV
Seminar series that engages students in interdisciplinary discussions about global health. Explores how bioengineering approaches contribute to: (1) the study of problems of global health importance; (2) the development of diagnostics; and (3) the discovery of interventional strategies to improve human health. Emphasizes collaboration between students and researchers with backgrounds in infectious disease, basic science, and bioengineering. Credit/no-credit only. Offered: jointly with G H 454; A.
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BIOEN 455 BioMEMS (4)
Introduction to BioMEMS. State-of-the-art techniques in patterning biomolecules, machining three-dimensional microstructures and building microfluidic devices. Various biomedical problems that can be addressed with microfabrication technology and the engineering challenges associated with it. Biweekly labs. Prerequisite: BIOEN 316. Offered: W.
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BIOEN 457 Advanced Molecular Bioengineering (4)
Fundamentals of molecular recognition: thermodynamics, forces, kinetics. Manipulation of recognition processes for current molecular bioengineering research and development. Fundamental physical chemistry of molecular recognition in the context of biomedicine. Therapeutics based on cells. Prerequisite: either BIOEN 315 and BIOEN 335. Offered: A.
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BIOEN 468 Real-Time Biosignal Processing (3)
Lab-based introduction to techniques for real-time signal acquisition, processing, and output, emphasizing software as an interface between user and electronic circuits. Students write programs for implementation both in graphical programming environments and in portable microprocessor platforms. In-depth discussion of hardware specifications and implications for circuit design. Prerequisite: Either BIOEN 316, or E E 215 and E E 235. Offered: W.
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BIOEN 470 Systems Immunology and Immunoengineering (3)
Explores current progress towards a quantitative, systems-level understanding of immune system function. Topics include sensitivity and selectivity in immune receptor signaling, cell-cell coordination by cytokine communication, and cell engineering for immunotherapy. Prerequisite: MATH 207 or AMATH 351.
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BIOEN 474 Immunoengineering (3)
Covers cell and tissues of immune system; lymphocyte activation and specificity; cell biology of antigen processing and preservation; and effector mechanisms. Includes discussion of concepts in theoretical immunology used to describe viral dynamics and the dynamics of immune responses. Students present case studies in the pathogenesis of immunologically mediated diseases. Offered: W.
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BIOEN 481 Engineering Cell Biology (3)
Introduces engineering approaches for analysis and control of cell structure and function, and application of such technologies in cell biology studies. Covers the basics of cell biology, engineering cellular microenvironments, as well as effects of external engineering stimuli on cellular processes, which have significant implications in various diseases such as cancer, neuromuscular disease, and cardiovascular disease. Prerequisite: either CHEM 142, CHEM 143, or CHEM 145; and BIOL 200; recommended: Introductory Biology, General Chemistry
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BIOEN 482 Cardiac Bioengineering (3)
Students discuss, present, and write literature reviews of scientific papers on the latest techniques, protocols and treatments being developed to treat heart failure and vascular diseases. Guest lecturers provide a clinical perspective, discuss clinical needs, and present their ongoing research and development projects. Prerequisite: BIOL 220; recommended: BIOEN 345.
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BIOEN 483 Vascular Biology and Engineering (3)
Vascular Engineering has emerged to provide strategies for generating vascular grafts with long-term patency, and vascularized tissues for regenerative medicine and disease modeling. Focuses on understanding the structure and function of different vascular beds in vivo, and learning the cutting edge research and engineering principles in vascular biology and engineering. Recommended: Introductory Biology, General Mechanics, and Cell Biology Offered: W.
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BIOEN 488 Computational Protein Design (4)
Explores methods in protein engineering, emphasizing biomedical and biotechnological applications. Includes molecular visualization, homology modeling, molecular dynamics, computational protein design, and evaluation of designs. Introduces current research in subject area. Students learn to use and apply computational tools to investigate design problems. Prerequisite: BIOEN 315. Offered: W.
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BIOEN 489 Advanced Tissue Engineering (3)
Develops advanced knowledge in tissue engineering. Primarily through critical assessment of seminal publications in areas such as biomaterials, biofabrication, organ decellularization, cellular self-organization, organoids, and regenerative medicine. Students identify groundbreaking studies in tissue engineering and communicate the impact to other scientists and the public. Prerequisite: BIOEN 486.
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