This is possible, but I would strongly advise not do do this. There are several issues when running another application on the foreground on a second display:
1) EPrime uses a non-colaborative display mode (DirectX). Any mouse or keyboard activity on the second screen will cause E-Run to crash. You can easily verify this. Also, the desktop of the second screen often shifts offscreen when E-Run changes display modes.
2) Timing could become an issue because EPrime fiddles with the application priorities and windows scheduler to increase timing accuracy. The other program might respond slow.