Hi Molly,
have you tried setting a "designated display" for each of your slides (Slide properties --> general properties --> display (choose one) )? The discovery of that feature solved many of these problems for me.
By changing the sizes of the images, do you mean the actual image, or the image size in eprime?
The first thing can be accomplished via IrfanView batch commands (you should find a simple explanation in google), and I guess you could use an Inline at the beginning of your experiment to reset all the imagebox sizes in Eprime itself at the start of each session of your experiment. This would be a bit of a drag, though...
Marc