Fwd: FW: ChBE Department Seminar by Dr Tan Yen Nee on 11 Mar 2014 (Tuesday), 2:30PM
Alvin Tan
From: Temasek_Labs@NUS <temase...@nus.edu.sg>
Date: Tue, Mar 4, 2014 at 6:47 PM
Subject: FW: ChBE Department Seminar by Dr Tan Yen Nee on 11 Mar 2014 (Tuesday), 2:30PM
To: TSL Staff <TSLS...@nus.edu.sg>
From: Janice Lim Yen Yong
Sent: Monday, 3 March, 2014 2:50 PM
To: NUS All Secretaries; CHE Staff; GSE CHE M.Eng. Students; GSE CHE Ph.D. Students; Office of Professional Engineering & Executive Education; steve.oh(BTI); Chia Zhi Wen; SMA CPE PhD July 06; SMA CPE PhD July 07; SMA CPE PhD July 08; SMA CPE PhD July 09; SMA CPE PhD July 10; Chua Lay Peng
Subject: ChBE Department Seminar by Dr Tan Yen Nee on 11 Mar 2014 (Tuesday), 2:30PM
Dear Secretaries,
Please assist to disseminate the announcement to your staff and students. Kindly refer to the attached PDF file if the announcement is not properly displayed. Thank you.
DEPARTMENTAL SEMINAR | ||
DePARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING Faculty of Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585 |
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Bioinspired Metal Nanoparticles and Their Biomedical Applications | ||
HOST |
A/Prof. Yang Kun-Lin Department of Chemical and Biomolecular Engineering | |
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DATE |
11th March 2014, Tuesday | |
TIME |
2:30-3:30PM | |
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VENUE |
E4-04-06, Faculty of Engineering, National University of Singapore NUS Campus Map & NUS: Faculty of Engineering | |
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SYNOPSIS |
Noble metal nanoparticles (NPs) such as silver and gold NPs, at the size range of 1-100 nm have attracted enormous scientific and technological interest due to their unique optical, electronic and catalytic properties, which are largely determined by their size, shape and crystal structure. Inspired by the natural biomineralization process on using biomolecular templates to form a range of sophisticated inorganic nanostructures, our current research efforts focus on the development of bioinspired metal NPs with tunable physicochemical properties that incorporate the highly specific recognition function of biomolecules for a vast plethora of biomedical applications in sensing, imaging, delivery and therapy. We have developed the first ‘bottom-up’ approach to design peptide- and nucleic acid-based biomolecular templates, for the synthesis of bioinspired metal NPs of different morphologies (e.g., Au nanoplates, nanowires, and Pt nanoboxes) and optical characteristics (i.e., plasmon absorption and light emission) with integrated biofunctionalities [1-5]. For example, we have designed the self-assembled DNA templates to form photoluminescent nanosilvers for redox-active molecules detection and imaging [4] as well as for antibacterial and toxin inhibition applications [5]. By exploiting the plasmonic coupling, fluorescence and/or light scattering properties of the biofunctionalized metal NPs, we have developed a series of metal nanoparticles-based bioassays for studying protein-DNA interactions [6-8], detecting DNA mutants with single nucleotide polymorphism [9], and monitoring enzymatic reaction [10]. These bioassays are versatile, efficient and low-cost with high throughput capability, which could culminate into tangible products useful for biomedical research and diagnostics.
References [1] Tan, Y.N.; Lee, J.Y.; Wang, Daniel. I.C. “Uncovering the Design Rules for Peptide Synthesis of Metal Nanoparticles.” J. Am. Chem. Soc. 2010, 132, 5677-5686. [2] Xie, J.; Tan, Y.N.; Lee, J.Y. “Biological and Biomimetic Syntheses of Metal Nanomaterials.” Book Chapter in Bio-mimetic and Bio-inspired Nanomaterials for Life Sciences, Wiley-VCH 2010, pp 251-282. [3] Tan, Y.N.; Lee, J.Y.; Wang, Daniel. I.C. “Morphosynthesis of Gold Nanoplates in Polypeptide Multilayer Films.” J. Phys. Chem. C. 2009, 113, 10887-10895. [4] Tan, Y.N.; Lim, Jason; Su, X.D., “Two-way Free Radical and Antioxidant Sensors using Redox-Responsive Fluorescent Metal Nanoclusters”, Singapore Patent 201304947-3, 2013 [5] Tan, Y.N.; Lim, Jason et al. “Method of Forming Controlled-Release Silver Nanocluster with Photoluminescent, Antimicrobial and Toxin Inhibition Properties”, Singapore Patent 201307789-6, 2013 [6] Tan, Y.N.; Su, X.D., Liu, E., Thomsen, J. S., “A Gold-Nanoparticle-Based Assay for Instantaneous Detection of Transcription Factor-DNA Interactions”. Anal. Chem. 2010, 82, 2759-2766. [7] Tan, Y.N.; Su X .D; Lee, J.Y., “Sensing of Transcription Factor through Controlled-Assembly of Metal Nanoparticles Modified with Segmented DNA Elements”. ACS Nano 2010, 4, 5101-5110. [8] Tan Y.N.; Su X.D., “A Study of DNA Design Dependency of Segmented DNA-Induced Gold Nanoparticle Aggregation towards Versatile Bioassay Development”. RSC Adv., 2013, 3, 21604-21612. [9] Tan, Y.N. et al, “Study of ssDNA Binding Protein-Nucleic Acid Interactions using Gold Nanoparticles and Its Application for Detection of Single Nucleotide Polymorphisms.” Anal. Chem. 2011, 83, 4251-57 [10] Tan Y. N.; Su X. D., “An Enzymatic Metal Nanoparticle Sensor for Detecting DNA Binders”, United State Patent 13/968,930, and Singapore Patent 201306257-5.
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BIOGRAPHY |
Dr Yen Nee Tan received her PhD degree in Molecular Engineering of the Chemical and Biological Systems from the National University of Singapore (NUS), under the prestigious Singapore-MIT Alliance program. She joined the Institute of Materials Research and Engineering (IMRE), A*STAR, Singapore in 2008. Since 2011, she has been the adjunct assistant professor at the Department of Chemistry, NUS. She is now heading the Bioinspired Materials Lab at IMRE. Her current research focuses on the biotemplating synthesis and biofunctionalization of optical bio-nanoprobes for sensing, imaging, delivery and therapy. She has published papers, reviews and book chapter in premier journals such as J. Am. Chem. Soc., ACS Nano, Anal. Chem., etc. and holds several professional appointments to serve in technical conferences, proposals review, international journals and scientific societies. Her recent scientific awards include the INNOVENT Best Pitching Award (2014), Loreal Women in Science Singapore, Finalist (2013), Tan Kah Kee Young Inventors’ Award (2012), Biomedical Engineering Society Best Presentation Award (2011) and AsiaNANO Young Researcher Award (2010). | |
A L L A R E W E L C O M E | ||
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Please visit our website for more details, http://www.chbe.nus.edu.sg/
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Thanks & Regards,
Janice Lim (Mdm) :: Management Assistant Officer, Department of Chemical & Biomolecular Engineering :: National University of Singapore :: Block E5 #02-09, 4 Engineering Drive 4, Singapore 117585 :: 65-6516 3044 (DID) :: 65-6779 1936 (Fax) :: che...@nus.edu.sg (E) :: www.chbe.nus.edu.sg (W):: Company Registration No: 200604346E
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