FDR testing: Volume or Number of Tracts?

[Mark Pinsk]

Hi Frank

Curious if you think FDR  testing should be done on volume or number of tracts?

I see here, at very bottom of page, you mention volume:

https://dsi-studio.labsolver.org/doc/gui_t3_dt.html

I don't have a sham scan, so I am calculating FDR based on increase in QA.

thx

Mark

[Fang-Cheng Yeh]

I would prefer volume because it is not a simulated quantity (as opposed to track counts).

Frank

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[Mark Pinsk]

That makes sense.  

I'm also seeing consistently higher FDR values (often >0.2) for FA compared to QA (often <0.2).  Is that something you would expect? 

This data is single-shell b=1K 90 directions.   I get many more tracts for QA too, which I assume is because it is a fiber-specific metric unlike FA.

[Fang-Cheng Yeh]

It depends on the studies. Some disease conditions may be more sensitive to FA.

Frank

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