I am having an issue with the strength and direction of correlations being extracted from data output from correlational tractograhy analyses. I followed the instructions on the website and created a scatter plot of bundle statistics vs an independent variable in excel. The correlations revealed in these plots are always weak and sometimes in the wrong direction. For example, change-in-QA stats loaded from neg.corr.tt.gz show a positive correlation when plotted against the independent variable used in the correlational tractography analysis. I have tried looking at the linear relationship between variables, parametric correlation coefficients, and spearmen coefficients and the result are all the same, occasional positive correlations are being displayed for a relationships that according to DSI Studios should be negative (and visa versa).
I have tried messing with the correlational tractography parameters using varying t-thresholds (2.5 - 4.0), length thresholds (25 - 35) and thread counts (4 - 64) and maintain an FDR < 0.05 but the correlations remain relatively unchanged, weak and sometimes in the wrong direction. What can I do to correct this issue?
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