Three groups setup

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Anna Kannonier

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Apr 2, 2026, 6:03:55 AM (11 days ago) Apr 2
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Hi Frank,

I have three groups (two intervention groups and one control group) and three scan time points (pre-, mid- and post-intervention). I have already created three separate databases for comparing the different time points.

What would be the best way to handle the three groups for pairwise comparisons?
Create separate databases again? or how would you set up the demographics?  

Thank you!
Anna

Frank Yeh

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Apr 8, 2026, 8:58:00 AM (5 days ago) Apr 8
to anna.ka...@gmail.com, DSI Studio
Hi Anna,

For the cross-sectional analysis, the best approach is to create a single database that includes all subjects. You can then use the cohort selection feature to include or exclude specific groups as needed for your comparisons.

Regarding the pre- and post-intervention comparisons, I recommend first computing the paired differences using the [Step C2] interface. This will allow you to generate the necessary difference maps before proceeding with further statistical analysis.

I hope this helps clarify the setup. Please let me know if you have any other questions.

Best regards,
Frank
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