Question about neonatal UF tractography differences in DSI Studio

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shashank bansal

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Mar 9, 2026, 7:06:21 AM (yesterday) Mar 9
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Dear Dr. Yeh,

I am working with diffusion MRI data from infants aged approximately 1–18 months, I am using DSI Studio to analyze the uncinate fasciculus (UF).

I generated UF tracts in two ways:

  1. Using the DSI Studio neonate group template.

  2. Using my own neonatal data reconstructed with QSDR into a human neonatal template.

My acquisition is single‑shell DTI with 15 directions at b=800 s/mm². Even when I apply AutoTrack with the UF atlas in template space, the UF rendered on my data looks noticeably different from the one on the DSI neonate template (more fragmented and with a different overall shape).

Could you please advise on the main reasons this discrepancy might occur (e.g., limitations of 15‑direction b=800 data, QSDR registration issues, or tracking thresholds tuned for the group template) and suggest parameter adjustments or best practices to obtain a more reliable UF reconstruction in this acquisition setting?

Best regards,
Shashank Bansal

Screenshot 2026-03-09 163547.png
template_tracts.png
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