Inquiry About Topup and Eddy Correction Methods in DSI Studio

[Candy CC]

Dear Frank,

I hope this message finds you well. I would like to express my sincere gratitude for developing and maintaining such a powerful and accessible tool for diffusion MRI analysis. It has been incredibly helpful in my research/work.

I am writing to kindly ask for some clarification regarding the underlying principles of how DSI Studio performs topup and eddy current correction. Specifically, I am interested in understanding:

Internal Principles: How does DSI Studio internally implement topup and eddy correction? What are the key methodologies or algorithms used?

Comparison with FSL: The gold standard tools for these corrections, FSL's topup and eddy, typically require reversed phase-encoded (blip-up/blip-down) acquisitions to accurately estimate field maps and correct for distortions. Why is DSI Studio able to perform these corrections effectively without the need for such reversed phase-encoding data?

Performance Difference: In your experience or based on validation studies, how significant is the difference in the quality of correction results between using FSL's topup and eddy compared to the methods implemented in DSI Studio? Are there specific scenarios where one might be preferred over the other?

Understanding these aspects would greatly help me in interpreting my results and choosing the most appropriate processing pipeline for my data.

Thank you very much for your time and consideration. I truly appreciate your work and would be very grateful for any insights you could share.

Best regards,
Yanxian Yue

[Frank Yeh]

Hi Yanxian,

    DSI Studio calls FSL to get the TOPUP/EDDY results. For details, you may check out tutorial videos at practicum.labsolver.org

Best regards,

Frank

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