Connectivity analysis between tumor and YEO atlas networks

[Clara Scherrer]

Hi!

I would like to analyze the influence a tumor may have on the brain's structural connectivity, more specifically on YEO networks (that I have already uploaded onto DSI Studio).

How would you recommend to proceed?

I tried 2 different approaches:

In the first I defined the tumor as a ROI when tracing tracts, and then calculated the connectivity matrix (as fiber count) between the YEO networks, both using "pass through" and "end in".

In the second, I selected each of the YEO networks and tumor as "END" regions when tracing the tracts. I then created a fiber count connectivity matrix between the "ROIs" this time.

Do these approaches make sense, and how would you interpret each of these?

Thank you so much in advance for your guidance.

Best regards,

Clara

[Frank Yeh]

I would like to analyze the influence a tumor may have on the brain's structural connectivity, more specifically on YEO networks (that I have already uploaded onto DSI Studio).

How would you recommend to proceed?

This is what I would do:

1. derive differential tractography between each patient and a group of controls.

2. use the results from differential tractography as the seed or ROI to get the entire affected tracts and compute their corresponding connectivity matrix.

Hope this helps,

Frank