Issues in automatic fiber tracking of arcuate fasciculus

[Yufan Wang]

Hi Frank,

I recently used atk to reconstruct arcuate fasciculus in HCP subjects and extracted tract-to-region connectome. However, I noticed that for several subjects (e.g., 178849, 463040), there were no detected intersections between the arcuate fasciculus and Brodmann areas 44 and 45. I have also observed similar cases in other datasets.

Given that the arcuate fasciculus is well known to connect to these regions, I was just wondering how this result should be interpreted.

Best,

Yufan

[Frank Yeh]

DSI Studio does not use Brodman areas to define the arcuate fasciculus. It will map pathway that similar to AF without using cortical surface information.

On the other hand, the parcellation of Brodman region is solely based spatial warping.

I think the problem could be due be 1). Tracking error, 2). Spatial warping misalignment. 3) AF does not connect Brodman 44, 45.

My humble opinion is that these three all have posibilities. 

Issue 1 and 2 are commonly discussed. Many technical papers have talked about these.

Issue 3 may also happen given that not all people have their language region associated with left 44, 45. It is less common, but still happens. I think this is one of the reason that in human tumor surgery, to avoid language deficit, there is a need for intra op stimulation, if the tumor is around.

I may ask more people about this and get back to this thread.

Frank

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