Heterogeneous FA Changes in Longitudinal Infant DTI Connectometry: Group-Level vs. Individual-Level Discrepancy

[shashank bansal]

Hi Dr. Yeh,

I hope this message finds you well. I am writing to seek your expert opinion on an observation from my longitudinal DTI connectometry analysis in infants with West syndrome.

I analyzed 17 longitudinal datasets (pre- and post-treatment, with pre-treatment scans used as baseline) using DSI Studio correlational tractography. The diffusion data were reconstructed to the inbuilt neonatal template space using QSDR. At the group level, the connectometry results showed a significant increase in FA (FDR = 0.000017), along with significant decreases in RD, MD, and AD across multiple white matter fiber bundles.

However, when I attempted an individual-level comparison by extracting tract-averaged FA values from the same identified fiber bundle, the post-treatment FA values tended to be lower rather than higher, and the paired t-test did not reach statistical significance. 

I would greatly appreciate any guidance or insight you may have on why this is happening?

Thank you very much for your time and consideration.

Best regards,
Shashank Bansal

[Frank Yeh]

Likely there is an error when extracting the tract FA values. 

If still cannot identify the cause, you may upload the database files, and I can check on my side.

Best regards,

Frank

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