Hi Paul,
You can do either ways, but there are pros and cons. If TE and TR
are different, then you may need to acquire a b0 for each TE/TR
combination. The b0 images can be used to calculate the T1W and T2W
and eliminate all T1- and T2 shine through for all DWI. Using the
minimum TR of the largest b scan and applying it to other scans saves
this hassle, but the total scanning time will be longer. DSI Studio
once had this multiple TE/TR correction routine built-in but was
removed due to poor performance at low SNR area. I would recommend you
use the same TE/TR for all scans. As multi-band sequence is getting
more popular in recent years, the scanning time should be the last
factor to consider.
DSI data split can be readily handled in DSI Studio. I used to
acquire multiple sets of scans for a DSI on Bruker scanners and
combined all of them in DSI Studio. For Phillips scans, you may put
all DICOM files under the same folder, and DSI Studio should be able
to load all of them just like they were collected all together. Should
there be any question about merging the dataset, please feel free to
let me know.
Best regards,
Frank
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