In one survey of 362 adults, 4 out of 5 said their depression decreased, and almost the same number said they felt less anxious. People who had stronger mystical experiences during their trip tended to feel better.[17]
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Another study asked 42 people in Europe how they felt after trying 5-MeO-DMT just once. They said they felt happier with their lives, and their depression, anxiety, and stress went down over the next month. People who felt a strong sense of being connected with the world reported the most improvement.[18]