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Bruce Kirchoff
Mar 31, 2009, 3:07:50 PM3/31/09
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dlre...@uncg.edu
Mar 31, 2009, 3:24:01 PM3/31/09
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I have one question about the scoring. If GLOCSA uses a mean column
heterogeneity score, would the GLOCSA component scores for each column
be a better column metric than the consistency scores currently being
displayed? I know the consistency score metric was my idea
originally, but pre-dates using the GLOCSA scores. While expected
heterozygosity is an appealing metric for consistency, it is still
rather ad hoc in the context of evolution on a phylogenetic tree and
does nothing to take into account that sequence evolution occurs in a
phylogenetic context.
Cheers,
Dave
heterogeneity score, would the GLOCSA component scores for each column
be a better column metric than the consistency scores currently being
displayed? I know the consistency score metric was my idea
originally, but pre-dates using the GLOCSA scores. While expected
heterozygosity is an appealing metric for consistency, it is still
rather ad hoc in the context of evolution on a phylogenetic tree and
does nothing to take into account that sequence evolution occurs in a
phylogenetic context.
Cheers,
Dave
Bruce Kirchoff
Mar 31, 2009, 3:36:50 PM3/31/09
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I definitely think that this is worth exploring. I think we need to
take a close look at all of the GLOCSA components and see how we can
tweak them to make them work best. Having the column scores = GLOCSA
scores would help with this.
Bruce
take a close look at all of the GLOCSA components and see how we can
tweak them to make them work best. Having the column scores = GLOCSA
scores would help with this.
Bruce
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