In order to play the DM48 as naturally as a standard chromatic harmonica, I have found that setting the MIDI Channel to Multich 1-4 (4 channels OUT) is a primary must followed by adjusting Sensitivity (adjusting the volume control on the amplifier output has the same effect for me), Trigger level, and Solo Assist to personally best suit the patches (instruments) within a VST plugin. The DAW I use is Mixcraft 8 Pro. In my early experiments playing the synthesised patches provided within Mixcraft, I found that I had to set up 4 separate instrument tracks 1 to 4 with MIDI channel IN of each track set to channels 1 to 4 respectively. I got garbled sound using only one track with the MIDI channel IN set to ALL. Some DAWS may have a feature where a group of MIDI channels IN can be selected.
Now that I have experimented with a number of more sophisticated VST plugins, I have found that using only one track with some VST plugins is sufficient provided the MIDI channel IN of that track is set to ALL within Mixcraft 8. With the same sophisticated VST plugins, if I use 4 tracks with MIDI channel IN set to 1 to 4 respectively, then each track records all MIDI notes. Using 4 tracks is therefore redundant if one is recording only a DM48 player. However, if a MIDI keyboard player is recorded simultaneously, then using 4 tracks and 4 MIDI channels IN for the DM48 and track 5 with MIDI channel IN set to 5 for the MIDI keyboard would be necessary in order to separate the MIDI content being recorded.