You may have already seen mention of virtualenv and pip wrt Django
development. I think there is a general consensus (among those who use
it anyway!) that it is essential for development (and I would recommend
it for deployment also).
Previous threads have described the advantages, but particularly for
Macs -- with their deep and otherwise non-standard and inscrutable
places to stash libraries and versions of tools -- the advantages of
using virtualenv and pip should not be ignored.
That said, I've *never* had an issue installing Django on my Mac (Lion
and MtnLion) using those tools. I also use MacPorts to give me control
over versioning for the base python, postgres, etc.
hth
- Tom