TRIZMA is the same as Tris?

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Mega [Andreas Stuermer]

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Mar 19, 2016, 1:24:53 PM3/19/16

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Just found the answer to a question and wanted to share.

It seems that Trizma is just a trademark name. But it is exactly the same as Tris. So if you read Trizma-HCl in a protocol, you can just get Tris-HCl.

The chemical formulas match, Sigma says NH₂C(CH₂OH)₃ · HCl for Trizma, Wikipedia says C4H11NO3 for Tris. The structural formula is ident. Both are powders, so you determine the concentration anyways.

So I am pretty sure you can substitute Trizma for Tris. Any objections?

Cory Tobin

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Mar 20, 2016, 4:19:43 AM3/20/16

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You are correct. Trizma is just Sigma's brand name for Tris. Just be sure to double check if the protocol requires Tris HCl or Tris Base. They are not equivalent.