Comprehensive Genome Project or Feasibility Thereof
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Cory Geesaman
Nov 20, 2014, 8:36:54 AM11/20/14
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I've been looking around with little success so figured I'd ask here. Does anyone know of a genome sequencing project aimed at mapping genomes of all known species? If none exist, how feasible would it be to get something like it going with modern technologies like Ion Torrent and maybe just refine the technique as you go to get something that could be used for analytics when trying to design a synthetic organism? The most comprehensive list I've found thus far is http://www.ncbi.nlm.nih.gov/genome/browse/ and it's pretty lacking (10,816 genomes mapped, only 1,149 in all of Eukaryota, 423 Animals, 9 Reptiles, etc). Anyone have insight into the operational costs of a project aimed at nothing more than mapping genomes (assume sample collection is free and just limit it to the actual equipment and labwork).
Cathal (Phone)
Nov 20, 2014, 8:46:15 AM11/20/14
to diy...@googlegroups.com, Cory Geesaman
To be clear, do you mean "is anyone just trying to generate a firehose of unprocessed sequence data for every living thing known to man"?
On 20 November 2014 13:36:54 GMT+00:00, Cory Geesaman <co...@geesaman.com> wrote:
I've been looking around with little success so figured I'd ask here. Does anyone know of a genome sequencing project aimed at mapping genomes of all known species? If none exist, how feasible would it be to get something like it going with modern technologies like Ion Torrent and maybe just refine the technique as you go to get something that could be used for analytics when trying to design a synthetic organism? The most comprehensive list I've found thus far is http://www.ncbi.nlm.nih.gov/genome/browse/ and it's pretty lacking (10,816 genomes mapped, only 1,149 in all of Eukaryota, 423 Animals, 9 Reptiles, etc). Anyone have insight into the operational costs of a project aimed at nothing more than mapping genomes (assume sample collection is free and just limit it to the actual equipment and labwork).
--
Sent from my Android device with K-9 Mail. Please excuse my brevity.
Sent from my Android device with K-9 Mail. Please excuse my brevity.
Cory Geesaman
Nov 20, 2014, 8:51:03 AM11/20/14
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Yes.
Cory Geesaman
Nov 20, 2014, 10:39:42 AM11/20/14
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Did some more research on this if anyone is interested.
Total Mbp to sequence (only cellular life): 10,031,623,401 - 14,211,856,834*
Total cost at current sequencing rate per Mbp: $501,581,170.00 - $710,592,841.70*
Total cost at lowest known sequencing rate per Mbp (a few months ago): $401,264,936.00 - $568,474,273.30*
*wide ranges are the result of wide estimates primarily in archaea and bacteria
Considering the Human Genome Project cost $2,700,000,000 it seems feasible given the massive price drop in sequencing (at least for cellular life - viroids are too difficult to estimate total numbers of)
Sources:
- Data from the previous link compiled down with a script to average Mbp/subgroup.
- http://www.genome.gov/sequencingcosts/ for the cost to sequence (about $0.05 / Mbp [up from $0.04 / Mbp earleir in the year])
- Sources around the web (mostly Wikipedia) for total numbers of cellular life by subgroup where availble and group or kingdom otherwise.
![Mega [Andreas Stuermer]'s profile photo](http://lh3.googleusercontent.com/a-/ALV-UjUNVm1hB8tAcAAFPeCKG7sAAOMXtiGvFTd7NEBaHFgxRcdy1Lnb=s40-c)
Mega [Andreas Stuermer]
Nov 20, 2014, 11:16:27 AM11/20/14
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Sequencing won't be that low for de novo sequencing of species I guess (?)
Cathal (Phone)
Nov 20, 2014, 11:51:49 AM11/20/14
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De novo is harder and more costly than resequencing, but not AFAIK by a factor of ten. So it seems Cory may be close to the mark, but the actual cost becomes person-hours, because de-novo certainly requires more *work*, and that's before you discuss assembly.
Nanopore may be just the ticket: extremely long, fast reads potentially in the field. Perfect for low-pass firehose sequence generation.
Nanopore may be just the ticket: extremely long, fast reads potentially in the field. Perfect for low-pass firehose sequence generation.
On 20 November 2014 16:16:27 GMT+00:00, "Mega [Andreas Stuermer]" <masters...@gmail.com> wrote:
Sequencing won't be that low for de novo sequencing of species I guess (?)
Dakota Hamill
Nov 20, 2014, 8:32:30 PM11/20/14
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Sequencing all species on earth would cost more than 500 million dollars unless I'm missing something
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Brian Degger
Nov 20, 2014, 8:52:31 PM11/20/14
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Rosetta cost $900 million+
So $500 million seems almost cheap.
To view this discussion on the web visit https://groups.google.com/d/msgid/diybio/CAGdeWmSi7%3DJ-dLoGyzd_KYb%3DXuAb_%2BqOj3L%2B0su8s1W87%2Bhpqg%40mail.gmail.com.
Brian Degger
Nov 20, 2014, 8:56:28 PM11/20/14
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And a tomahawk missile costs $1.4 million (and Raytheon has sold 2000 of them)
Dakota Hamill
Nov 20, 2014, 8:57:52 PM11/20/14
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Murca
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Dakota Hamill
Nov 20, 2014, 9:05:39 PM11/20/14
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The defense budget fucks my mind. Put 500 billion into science, engineering, and education for one year and people wouldn't want to kill each other because everyone's problems would be solved in a year. Its just so sad the amount we spend to prepare for killing each other. At our stage of nuclear development a world war would be the end, so it's not conducive for any superpower to go to war. We should invest in technology, but no scientists want to be politicians because its fucking corrupt
Dakota Hamill
Nov 20, 2014, 9:09:43 PM11/20/14
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Unfortunately the world doesn't work without inequality
Cathal Garvey
Nov 21, 2014, 6:37:43 AM11/21/14
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[citation needed]
On 21/11/14 02:09, Dakota Hamill wrote:
> Unfortunately the world doesn't work without inequality
>
> On Nov 20, 2014 9:05 PM, "Dakota Hamill" <dko...@gmail.com
> <mailto:diybio%2Bunsu...@googlegroups.com>. For
> Learn more at www.diybio.org <http://www.diybio.org>
> <mailto:diy...@googlegroups.com>.
> <mailto:diybio%2Bunsu...@googlegroups.com>. For
> Learn more at www.diybio.org <http://www.diybio.org>
> <mailto:diy...@googlegroups.com>.
> <https://groups.google.com/d/msgid/diybio/CAGdeWmSi7%3DJ-dLoGyzd_KYb%3DXuAb_%2BqOj3L%2B0su8s1W87%2Bhpqg%40mail.gmail.com?utm_medium=email&utm_source=footer>.
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On 21/11/14 02:09, Dakota Hamill wrote:
> Unfortunately the world doesn't work without inequality
>
> On Nov 20, 2014 9:05 PM, "Dakota Hamill" <dko...@gmail.com
> <mailto:dko...@gmail.com>> wrote:
>
> The defense budget fucks my mind. Put 500 billion into science,
> engineering, and education for one year and people wouldn't want to
> kill each other because everyone's problems would be solved in a
> year. Its just so sad the amount we spend to prepare for killing
> each other. At our stage of nuclear development a world war would
> be the end, so it's not conducive for any superpower to go to
> war. We should invest in technology, but no scientists want to be
> politicians because its fucking corrupt
>
> On Nov 20, 2014 8:57 PM, "Dakota Hamill" <dko...@gmail.com
>
> The defense budget fucks my mind. Put 500 billion into science,
> engineering, and education for one year and people wouldn't want to
> kill each other because everyone's problems would be solved in a
> year. Its just so sad the amount we spend to prepare for killing
> each other. At our stage of nuclear development a world war would
> be the end, so it's not conducive for any superpower to go to
> war. We should invest in technology, but no scientists want to be
> politicians because its fucking corrupt
>
> On Nov 20, 2014 8:57 PM, "Dakota Hamill" <dko...@gmail.com
> <mailto:dko...@gmail.com>> wrote:
>
> Murca
>
> On Nov 20, 2014 8:56 PM, "Brian Degger" <brian....@gmail.com
>
> Murca
>
> On Nov 20, 2014 8:56 PM, "Brian Degger" <brian....@gmail.com
> <mailto:brian....@gmail.com>> wrote:
>
> And a tomahawk missile costs $1.4 million (and Raytheon has
> sold 2000 of them)
>
> On 21 Nov 2014 01:52, "Brian Degger" <brian....@gmail.com
>
> And a tomahawk missile costs $1.4 million (and Raytheon has
> sold 2000 of them)
>
> On 21 Nov 2014 01:52, "Brian Degger" <brian....@gmail.com
> <mailto:brian....@gmail.com>> wrote:
>
> Rosetta cost $900 million+
> So $500 million seems almost cheap.
>
> On 21 Nov 2014 01:32, "Dakota Hamill" <dko...@gmail.com
>
> Rosetta cost $900 million+
> So $500 million seems almost cheap.
>
> On 21 Nov 2014 01:32, "Dakota Hamill" <dko...@gmail.com
> <mailto:dko...@gmail.com>> wrote:
>
> Sequencing all species on earth would cost more than
> 500 million dollars unless I'm missing something
>
> De novo is harder and more costly than resequencing,
> but not AFAIK by a factor of ten. So it seems Cory
> may be close to the mark, but the actual cost
> becomes person-hours, because de-novo certainly
> requires more *work*, and that's before you discuss
> assembly.
>
> Nanopore may be just the ticket: extremely long,
> fast reads potentially in the field. Perfect for
> low-pass firehose sequence generation.
>
> On 20 November 2014 16:16:27 GMT+00:00, "Mega
> [Andreas Stuermer]" <masters...@gmail.com
>
> Sequencing all species on earth would cost more than
> 500 million dollars unless I'm missing something
>
> De novo is harder and more costly than resequencing,
> but not AFAIK by a factor of ten. So it seems Cory
> may be close to the mark, but the actual cost
> becomes person-hours, because de-novo certainly
> requires more *work*, and that's before you discuss
> assembly.
>
> Nanopore may be just the ticket: extremely long,
> fast reads potentially in the field. Perfect for
> low-pass firehose sequence generation.
>
> On 20 November 2014 16:16:27 GMT+00:00, "Mega
> [Andreas Stuermer]" <masters...@gmail.com
> <mailto:masters...@gmail.com>> wrote:
>
> Sequencing won't be that low for de novo sequencing of species I guess (?)
>
>
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> excuse my brevity.
>
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> Sequencing won't be that low for de novo sequencing of species I guess (?)
>
>
> --
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> excuse my brevity.
>
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Cathal Garvey
Nov 21, 2014, 6:41:29 AM11/21/14
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Essential problem here: You can't, as a politician, invest in "science
and technology" personally and then invest state funds in the field to
make yourself a billionaire. But you can for many industries; oil and
gas, copyright, and war. And it just so happens that War is one of the
most reliable ways to achieve this, because you aren't just abusing your
political position to twist the market, you can also abuse your position
to twist diplomacy and encourage a war.
Also, due to your influence, Copyright Inc might get a proportional
boost, but they were in business before and after your influence. In
peacetime, War Inc is worth little, but when you start a war, the
proportional increase in share value is sudden and drastic.
So, logically, investing in War Inc and starting a war is the best bet
for a powerful and influential politician, who (thanks to her ape brain)
is already probably a sociopath because of the weight of the authority
she bears, making that logical investment decision easier to make.
Where is your invisible hand, now? Markets, shares and investment kill
as surely as Tomahawks.
On 21/11/14 02:05, Dakota Hamill wrote:
> The defense budget fucks my mind. Put 500 billion into science,
> engineering, and education for one year and people wouldn't want to kill
> each other because everyone's problems would be solved in a year. Its
> just so sad the amount we spend to prepare for killing each other. At
> our stage of nuclear development a world war would be the end, so it's
> not conducive for any superpower to go to war. We should invest in
> technology, but no scientists want to be politicians because its fucking
> corrupt
>
> On Nov 20, 2014 8:57 PM, "Dakota Hamill" <dko...@gmail.com
> <mailto:diybio%2Bunsu...@googlegroups.com>. For more
> Learn more at www.diybio.org <http://www.diybio.org>
> <mailto:diybio%2Bunsu...@googlegroups.com>. For more
> Learn more at www.diybio.org <http://www.diybio.org>
> <https://groups.google.com/d/msgid/diybio/CAGdeWmSi7%3DJ-dLoGyzd_KYb%3DXuAb_%2BqOj3L%2B0su8s1W87%2Bhpqg%40mail.gmail.com?utm_medium=email&utm_source=footer>.
> <mailto:diybio%2Bunsu...@googlegroups.com>. For more
> Learn more at www.diybio.org <http://www.diybio.org>
> <https://groups.google.com/d/msgid/diybio/CACc%3DpRLkHu2-f6Qu1%2BAqn8h%2BaNtTp4jgS9gLwGFJRCEK0fK9dg%40mail.gmail.com?utm_medium=email&utm_source=footer>.
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and technology" personally and then invest state funds in the field to
make yourself a billionaire. But you can for many industries; oil and
gas, copyright, and war. And it just so happens that War is one of the
most reliable ways to achieve this, because you aren't just abusing your
political position to twist the market, you can also abuse your position
to twist diplomacy and encourage a war.
Also, due to your influence, Copyright Inc might get a proportional
boost, but they were in business before and after your influence. In
peacetime, War Inc is worth little, but when you start a war, the
proportional increase in share value is sudden and drastic.
So, logically, investing in War Inc and starting a war is the best bet
for a powerful and influential politician, who (thanks to her ape brain)
is already probably a sociopath because of the weight of the authority
she bears, making that logical investment decision easier to make.
Where is your invisible hand, now? Markets, shares and investment kill
as surely as Tomahawks.
On 21/11/14 02:05, Dakota Hamill wrote:
> The defense budget fucks my mind. Put 500 billion into science,
> engineering, and education for one year and people wouldn't want to kill
> each other because everyone's problems would be solved in a year. Its
> just so sad the amount we spend to prepare for killing each other. At
> our stage of nuclear development a world war would be the end, so it's
> not conducive for any superpower to go to war. We should invest in
> technology, but no scientists want to be politicians because its fucking
> corrupt
>
> On Nov 20, 2014 8:57 PM, "Dakota Hamill" <dko...@gmail.com
> <mailto:dko...@gmail.com>> wrote:
>
> Murca
>
> On Nov 20, 2014 8:56 PM, "Brian Degger" <brian....@gmail.com
>
> Murca
>
> On Nov 20, 2014 8:56 PM, "Brian Degger" <brian....@gmail.com
> <mailto:brian....@gmail.com>> wrote:
>
> And a tomahawk missile costs $1.4 million (and Raytheon has sold
> 2000 of them)
>
> On 21 Nov 2014 01:52, "Brian Degger" <brian....@gmail.com
>
> And a tomahawk missile costs $1.4 million (and Raytheon has sold
> 2000 of them)
>
> On 21 Nov 2014 01:52, "Brian Degger" <brian....@gmail.com
> <mailto:brian....@gmail.com>> wrote:
>
> Rosetta cost $900 million+
> So $500 million seems almost cheap.
>
> On 21 Nov 2014 01:32, "Dakota Hamill" <dko...@gmail.com
>
> Rosetta cost $900 million+
> So $500 million seems almost cheap.
>
> On 21 Nov 2014 01:32, "Dakota Hamill" <dko...@gmail.com
> <mailto:dko...@gmail.com>> wrote:
>
> Sequencing all species on earth would cost more than 500
> million dollars unless I'm missing something
>
> De novo is harder and more costly than resequencing, but
> not AFAIK by a factor of ten. So it seems Cory may be
> close to the mark, but the actual cost becomes
> person-hours, because de-novo certainly requires more
> *work*, and that's before you discuss assembly.
>
> Nanopore may be just the ticket: extremely long, fast
> reads potentially in the field. Perfect for low-pass
> firehose sequence generation.
>
> On 20 November 2014 16:16:27 GMT+00:00, "Mega [Andreas
> Stuermer]" <masters...@gmail.com
>
> Sequencing all species on earth would cost more than 500
> million dollars unless I'm missing something
>
> De novo is harder and more costly than resequencing, but
> not AFAIK by a factor of ten. So it seems Cory may be
> close to the mark, but the actual cost becomes
> person-hours, because de-novo certainly requires more
> *work*, and that's before you discuss assembly.
>
> Nanopore may be just the ticket: extremely long, fast
> reads potentially in the field. Perfect for low-pass
> firehose sequence generation.
>
> On 20 November 2014 16:16:27 GMT+00:00, "Mega [Andreas
> Stuermer]" <masters...@gmail.com
> <mailto:masters...@gmail.com>> wrote:
>
> Sequencing won't be that low for de novo sequencing of species I guess (?)
>
>
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> Sequencing won't be that low for de novo sequencing of species I guess (?)
>
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Brian Degger
Nov 21, 2014, 6:48:47 AM11/21/14
to diy...@googlegroups.com
Cathal,
One of those Feindishly Devilish Problems .. how to stop the trickle up ;)
> email to diybio+un...@googlegroups.com.
----------------------------------------
Brian Degger
twitter: @drbrian
http://makerspace.org.uk
http://transitlab.org
----------------------------------------
One of those Feindishly Devilish Problems .. how to stop the trickle up ;)
> To post to this group, send email to diy...@googlegroups.com.
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Cory Geesaman
Nov 21, 2014, 7:55:07 AM11/21/14
to diy...@googlegroups.com, cathal...@cathalgarvey.me
When you put it that way it seems like science and tech could be spurred just by having more scientists willing to give kickbacks to politicians that support them.
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SC
Nov 21, 2014, 7:57:11 AM11/21/14
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There are groups that are focusing on genome sequencing of large numbers of different taxa:
And also this from the Smithsonian
I personally think this is a great idea and have focused my home lab (and small budget) on it. I have a freezer full of samples and as money trickles in I run sequencing reactions. I don't think I'll live long enough to see the completion of all ~2M species.
Incidently, i have found that the most cost effective way to sequence a de-novo complex genome is a combination of 50X PacBio and 100X paired-end Illumina. The PacBio is a longer read with a higher error rate, and the illumina is a more accurate shorter read. Assemble the PacBio reads to make scaffolds, then align the higher accuracy Illumina reads on the scaffolds. I also like BAC clones.
Matt Lawes
Nov 21, 2014, 8:42:21 AM11/21/14
to diy...@googlegroups.com
Perhaps if we hung corrupt politicians?
It would take a lot of rope and some time. But we would end up with representatives of the electorate.
>matt
Sent from my Verizon Wireless 4G LTE DROID
Brian Degger <brian....@gmail.com> wrote:
Cathal,
One of those Feindishly Devilish Problems .. how to stop the trickle up ;)
On Fri, Nov 21, 2014 at 11:41 AM, Cathal Garvey
One of those Feindishly Devilish Problems .. how to stop the trickle up ;)
On Fri, Nov 21, 2014 at 11:41 AM, Cathal Garvey
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Cathal Garvey
Nov 21, 2014, 11:53:34 AM11/21/14
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I think the problem is "electorate". Elections mean popularity contests,
and that attracts and rewards a certain type of person.
The Athenians used sortition. Democracy isn't always electoral. I'll
wager electoral democracies have the odds stacked against equitable
governance from the outset, based on my observations of my own country
and virtually every other Anglophone nation out there.
Hanging politicians will just breed better liars; evolution, etcetera.
On 21/11/14 13:42, Matt Lawes wrote:
> Perhaps if we hung corrupt politicians?
> It would take a lot of rope and some time. But we would end up with
> representatives of the electorate.
> >matt
>
> /Sent from my Verizon Wireless 4G LTE DROID/
> <https://groups.google.com/d/msgid/diybio/st8om9ujhio2ul7ao8wvlfyc.1416577316689%40email.android.com?utm_medium=email&utm_source=footer>.
and that attracts and rewards a certain type of person.
The Athenians used sortition. Democracy isn't always electoral. I'll
wager electoral democracies have the odds stacked against equitable
governance from the outset, based on my observations of my own country
and virtually every other Anglophone nation out there.
Hanging politicians will just breed better liars; evolution, etcetera.
On 21/11/14 13:42, Matt Lawes wrote:
> Perhaps if we hung corrupt politicians?
> It would take a lot of rope and some time. But we would end up with
> representatives of the electorate.
> >matt
>
> https://groups.google.com/d/msgid/diybio/CAGdeWmSRa104Ra5_ygiDd%3DhvBzNjG5GAPiNSm7K2ybEpFK7eXQ%40mail.gmail.com
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Cory Geesaman
Nov 21, 2014, 12:05:02 PM11/21/14
to diy...@googlegroups.com, cathal...@cathalgarvey.me
The US actually had more of republic overtone earlier on - originally the president was a popularity contest, the house was a very localized democracy and the senate was put in office by the various state governments. The 17th amendment made it so the senate was voted for democratically and turned all three branches into a popularity contest while removing virtually all state influence at the federal level (and all because of the strawman that "it might lead to corruption" if the states were allowed to put senators in power instead of making it into a popularity contest).
> >> <mailto:diybio%2Bu...@googlegroups.com>. For more
> >> <mailto:diybio%2Bu...@googlegroups.com>. For more
> >> <mailto:diybio%2Bu...@googlegroups.com>. For more
Cathal Garvey
Nov 21, 2014, 12:16:28 PM11/21/14
to diy...@googlegroups.com
If I had my way with Ireland tomorrow I'd hedge my bets: I'd make one
house pure-sortition, and the other liquid-democracy, and install a
working-group based system instead of canonical "Ministers". Our
presidential office is fine the way it is, honestly; it's just a
figurehead/veto office, we don't have a hegemony at all in that respect.
The whole idea of electing "representatives" makes sense when people
don't want to engage in politics to the extent that everything becomes a
referendum. Having vote-delegating liquid democracy gives a nice middle
ground. Make *everything* a network-mediated referendum, and allow
people to delegate their uncast votes to someone else; this filters up
into a set of "elected representatives", but only insofar as people
don't cast their votes in their local ballot office; in other words,
there is a fluid "government" only as far as the electorate agree with
what they tend to spend their delegated votes on. If they annoy people
enough to reassign their votes, their voting base collapses and they are
out of their (implied) "office".
The sortition-house, meanwhile, have a longer term, allowing them to do
the "difficult", non-populist stuff, and are candidates for "ministry"
working groups. But their term can never be renewed, so there's no
electoral cycle. They have 1-2 years to do what matters, and that's it.
They get paid the median wage of the country according to the most
recent census.
> <javascript:>
> > >> <mailto:masters...@gmail.com <javascript:>>>
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> > >> <mailto:diy...@googlegroups.com <javascript:>>.
> <https://groups.google.com/d/msgid/diybio/546F24D6.2030709%40cathalgarvey.me>.
> <https://groups.google.com/d/optout>.
> group, send email to
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house pure-sortition, and the other liquid-democracy, and install a
working-group based system instead of canonical "Ministers". Our
presidential office is fine the way it is, honestly; it's just a
figurehead/veto office, we don't have a hegemony at all in that respect.
The whole idea of electing "representatives" makes sense when people
don't want to engage in politics to the extent that everything becomes a
referendum. Having vote-delegating liquid democracy gives a nice middle
ground. Make *everything* a network-mediated referendum, and allow
people to delegate their uncast votes to someone else; this filters up
into a set of "elected representatives", but only insofar as people
don't cast their votes in their local ballot office; in other words,
there is a fluid "government" only as far as the electorate agree with
what they tend to spend their delegated votes on. If they annoy people
enough to reassign their votes, their voting base collapses and they are
out of their (implied) "office".
The sortition-house, meanwhile, have a longer term, allowing them to do
the "difficult", non-populist stuff, and are candidates for "ministry"
working groups. But their term can never be renewed, so there's no
electoral cycle. They have 1-2 years to do what matters, and that's it.
They get paid the median wage of the country according to the most
recent census.
> > >> <mailto:dko...@gmail.com <javascript:>>> wrote:
> > >>
> > >> Murca
> > >>
> > >> On Nov 20, 2014 8:56 PM, "Brian Degger"
> <brian....@gmail.com <javascript:>
> > >>
> > >> Murca
> > >>
> > >> On Nov 20, 2014 8:56 PM, "Brian Degger"
> > >> <mailto:brian....@gmail.com <javascript:>>> wrote:
> > >>
> > >> And a tomahawk missile costs $1.4 million (and
> Raytheon has sold
> > >> 2000 of them)
> > >>
> > >> On 21 Nov 2014 01:52, "Brian Degger"
> <brian....@gmail.com <javascript:>
> > >>
> > >> And a tomahawk missile costs $1.4 million (and
> Raytheon has sold
> > >> 2000 of them)
> > >>
> > >> On 21 Nov 2014 01:52, "Brian Degger"
> > >> <mailto:brian....@gmail.com <javascript:>>> wrote:
> > >>
> > >> Rosetta cost $900 million+
> > >> So $500 million seems almost cheap.
> > >>
> > >> On 21 Nov 2014 01:32, "Dakota Hamill"
> <dko...@gmail.com <javascript:>
> > >>
> > >> Rosetta cost $900 million+
> > >> So $500 million seems almost cheap.
> > >>
> > >> On 21 Nov 2014 01:32, "Dakota Hamill"
> > >> <mailto:dko...@gmail.com <javascript:>>> wrote:
> > >>
> > >> Sequencing all species on earth would cost
> more than 500
> > >> million dollars unless I'm missing something
> > >>
> > >> De novo is harder and more costly than
> resequencing, but
> > >> not AFAIK by a factor of ten. So it seems
> Cory may be
> > >> close to the mark, but the actual cost becomes
> > >> person-hours, because de-novo certainly
> requires more
> > >> *work*, and that's before you discuss assembly.
> > >>
> > >> Nanopore may be just the ticket: extremely
> long, fast
> > >> reads potentially in the field. Perfect for
> low-pass
> > >> firehose sequence generation.
> > >>
> > >> On 20 November 2014 16:16:27 GMT+00:00, "Mega
> [Andreas
> > >> Stuermer]" <masters...@gmail.com <javascript:>
> > >>
> > >> Sequencing all species on earth would cost
> more than 500
> > >> million dollars unless I'm missing something
> > >>
> > >> De novo is harder and more costly than
> resequencing, but
> > >> not AFAIK by a factor of ten. So it seems
> Cory may be
> > >> close to the mark, but the actual cost becomes
> > >> person-hours, because de-novo certainly
> requires more
> > >> *work*, and that's before you discuss assembly.
> > >>
> > >> Nanopore may be just the ticket: extremely
> long, fast
> > >> reads potentially in the field. Perfect for
> low-pass
> > >> firehose sequence generation.
> > >>
> > >> On 20 November 2014 16:16:27 GMT+00:00, "Mega
> [Andreas
> > >> <mailto:masters...@gmail.com <javascript:>>>
> wrote:
> > >>
> > >> Sequencing won't be that low for de novo
> > sequencing of
> > >> species I guess (?)
> > >>
> > >>
> > >> --
> > >> Sent from my Android device with K-9 Mail.
> Please excuse
> > >> my brevity.
> > >>
> > >> --
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> <javascript:>
> > >>
> > >> Sequencing won't be that low for de novo
> > sequencing of
> > >> species I guess (?)
> > >>
> > >>
> > >> --
> > >> Sent from my Android device with K-9 Mail.
> Please excuse
> > >> my brevity.
> > >>
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> > >>
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>
> > >>
> > >>
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> <https://groups.google.com/d/msgid/diybio/3DCB8481-C126-4A88-9FDC-2C3237C33F62%40cathalgarvey.me?utm_medium=email&utm_source=footer>>.
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>
> > >>
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> <https://groups.google.com/d/msgid/diybio/CAGdeWmSi7%3DJ-dLoGyzd_KYb%3DXuAb_%2BqOj3L%2B0su8s1W87%2Bhpqg%40mail.gmail.com?utm_medium=email&utm_source=footer
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>
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> >
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>
> > >>
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> <https://groups.google.com/d/msgid/diybio/CACc%3DpRLkHu2-f6Qu1%2BAqn8h%2BaNtTp4jgS9gLwGFJRCEK0fK9dg%40mail.gmail.com?utm_medium=email&utm_source=footer
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>
> > >>
> > >>
> >
> <https://groups.google.com/d/msgid/diybio/CACc%3DpRLkHu2-f6Qu1%2BAqn8h%2BaNtTp4jgS9gLwGFJRCEK0fK9dg%40mail.gmail.com?utm_medium=email&utm_source=footer>>.
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> > >>
> > >>
> >
> https://groups.google.com/d/msgid/diybio/CAGdeWmSRa104Ra5_ygiDd%3DhvBzNjG5GAPiNSm7K2ybEpFK7eXQ%40mail.gmail.com
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>
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Matt Lawes
Nov 21, 2014, 1:11:48 PM11/21/14
to diy...@googlegroups.com
Definitely in favor of repealing 17th amendment and reasserting States rights in Washington. Might as well repeal 16th too while at it (federal income taxes).
>matt
Sent from my Verizon Wireless 4G LTE DROID
> >> <mailto:dko...@gmail.com>> wrote:
> >>
> >> Murca
> >>
> >> On Nov 20, 2014 8:56 PM, "Brian Degger" <brian....@gmail.com
> >> <mailto:brian....@gmail.com>> wrote:
> >>
> >> And a tomahawk missile costs $1.4 million (and Raytheon has sold
> >> 2000 of them)
> >>
> >> On 21 Nov 2014 01:52, "Brian Degger" <brian....@gmail.com
> >> <mailto:brian....@gmail.com>> wrote:
> >>
> >> Rosetta cost $900 million+
> >> So $500 million seems almost cheap.
> >>
> >> On 21 Nov 2014 01:32, "Dakota Hamill" <dko...@gmail.com
> >> <mailto:dko...@gmail.com>> wrote:
> >>
> >> Sequencing all species on earth would cost more than 500
> >> million dollars unless I'm missing something
> >>
> >> De novo is harder and more costly than resequencing, but
> >> not AFAIK by a factor of ten. So it seems Cory may be
> >> close to the mark, but the actual cost becomes
> >> person-hours, because de-novo certainly requires more
> >> *work*, and that's before you discuss assembly.
> >>
> >> Nanopore may be just the ticket: extremely long, fast
> >> reads potentially in the field. Perfect for low-pass
> >> firehose sequence generation.
> >>
> >> On 20 November 2014 16:16:27 GMT+00:00, "Mega [Andreas
> >> Stuermer]" <masters...@gmail.com
> >> <mailto:masters...@gmail.com>> wrote:
> >>
> >> Sequencing won't be that low for de novo
> sequencing of
> >> species I guess (?)
> >>
> >>
> >> --
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> >> my brevity.
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