Animal Genetic Engineering

[Brian Amburn]

Hi all,

I want to genetically enhance animals.  I would like to give extra functions to mice and maybe attempt to make them more intelligent and possibly muscular, maybe try to make them live longer too.  I understand this would be incredibly difficult, but it's what I want to do.  I also understand that ethical concerns would be made, and that I would need to cross them/answer them.  I have a rather good understanding of genetics (college level) but I have no true microbiology/genetics lab experience.  I would certainly appreciate anyone helping me find out what I would need to try this including equipment, knowledge, genes, etc.  Also if anyone could help me better understand how to do this I would greatly appreciate that.  In time I will gain more experience in this field as I am taking more classes and will likely be working in a lab soon.  I'm just incredibly interested and passionate about this stuff, so I would love some help.

Thanks,

Brian

[Felipe Tanaami]

For sure it's a hard task. I suggest you to start with bacteria, doing simple experiments first, because much of the skills you will learn will be used in mammalian cells, but is a lot easier and you wont fail like you will if you start with advanced techniques. There are lot of material to study on the internet, like biobuilder.org, and being affiliated with a biohackerspace would be great, since they will have lots of equipments and people who might help you.

[Brian Amburn]

Thanks for suggesting that site, I'll look into doing those experiments, and sadly as it turns out there's no biohackerspace near me, so I might have to start my own.

[Mega [Andreas Stuermer]]

Check out sperm-mediated transformation. All you need then is PCRing together a construct - or having it synthesized if you can afford. And obviously a way to collect sperm from the animal you want enhance (I don't recommend tigers).

[Mega [Andreas Stuermer]]

Make sure to consider the ethics. If you make mice much smarter, they may be considered human-like sentient beings and you should make sure to treat them well, big cage, toys, food, magazines, etc.

On Tuesday, December 13, 2016 at 4:14:12 AM UTC+1, Brian Amburn wrote:

[Felipe Tanaami]

Next polemics: Should intelligent mice be used in psychiatrics experiments?

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[Simon Quellen Field]

Don't make them smart enough to avoid mousetraps.

It's hard enough building better mousetraps without people going around building better mice.

:-)

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[Vytautas Guzas]

Fun coincidence: I recently read a Philip K. Dick novel about a dystopian future where such mice (and other animals existed). One of the protagonists was a travelling "advanced mousetrap" salesman. Apparently, people adapted to the situation, I hope we will too :D.

On Monday, December 19, 2016 at 10:34:58 AM UTC+13, Simon Field wrote:

Don't make them smart enough to avoid mousetraps.

It's hard enough building better mousetraps without people going around building better mice.

:-)

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On Sun, Dec 18, 2016 at 1:23 PM, Felipe Tanaami <tan...@gmail.com> wrote:

Next polemics: Should intelligent mice be used in psychiatrics experiments?

2016-12-18 18:15 GMT-02:00 Mega [Andreas Stuermer] <masters...@gmail.com>:

Make sure to consider the ethics. If you make mice much smarter, they may be considered human-like sentient beings and you should make sure to treat them well, big cage, toys, food, magazines, etc.




On Tuesday, December 13, 2016 at 4:14:12 AM UTC+1, Brian Amburn wrote:

Hi all,

I want to genetically enhance animals.  I would like to give extra functions to mice and maybe attempt to make them more intelligent and possibly muscular, maybe try to make them live longer too.  I understand this would be incredibly difficult, but it's what I want to do.  I also understand that ethical concerns would be made, and that I would need to cross them/answer them.  I have a rather good understanding of genetics (college level) but I have no true microbiology/genetics lab experience.  I would certainly appreciate anyone helping me find out what I would need to try this including equipment, knowledge, genes, etc.  Also if anyone could help me better understand how to do this I would greatly appreciate that.  In time I will gain more experience in this field as I am taking more classes and will likely be working in a lab soon.  I'm just incredibly interested and passionate about this stuff, so I would love some help.

Thanks,

Brian

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