surface plasmon resonance

[Dan Bolser]

Can anyone build me one of these:

http://www.biacore.com/lifesciences/technology/introduction/following_interaction/index.html

What cost?

I want to develop specific inbibitors of mitochondrial transporters.

kthxbi

[Nathan McCorkle]

i've seen some stuff on SPR detectors before, but I'm pretty sure you still need the surface to be functionalized, and this would detect binding, so not sure how you would use SPR to develop mito transporter inhibitors

cost is expensive (several thousands to hundreds of thousands, depending on production of developed designs vs research), since this is still predominantly big-lab big-money research

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-Nathan

[Dan Bolser]

You can use some kind of polymer emulsion to fix membrane proteins on
the surface, then wash with a chemical library to detect binding.

Yeah, just wondering how to drive down costs...