Do cells of the same type in different species act differently with the same DNA?

[Cory Geesaman]

That is if you took something like a liver cell of a giraffe and a lizard and switched the DNA or an embryonic stem cell of a walrus and a frog and switched the DNA would the cell operate under the new set of DNA or would there be variations either due to genes that had already been expressed in building the cell or intracellular machinery that is species-specific?

[Mega [Andreas Stuermer]]

Difficult to say. After some generations it should be identical to original species I guess. 

Vertebrates will be pretty much the same - tRNAs, ribosomes, polymerases. It could work intraspecially. 

Hope I got the question right,

like (extreme case) say you want human embryonic stem cells of yourself. You don't want to kill a human fertilized egg cell for it, so you take the fertilized egg cell of a cow and replace the cow nucleus by your nucleus. 

Your embryonic stem cell will have the mitochondria of a cow, but I don't think they wouldn't work. 

[Brian Degger]

Back of the envelope thinking.
Cytoplasmic hybrids like cow - human nucleus stop dividing pretty early.
Think about endothermic and exothermic too organisms too, changes.
Red blood cells....Some adapted to hight altitude oxygen concentrations...Some for sea level.
Like the species of geese that can fly much higher than the rest.

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[Will Sutton]

Don't forget mtDNA as well...http://www.npr.org/blogs/health/2014/11/10/360342623/combining-the-dna-of-three-people-raises-ethical-questions

[Brian Degger]

Yeah Yeah,
mtDNA too...
Everything is more complicated.
and Epigenetics, imprinting, etc

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Brian Degger
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[Yuriy Fazylov]

http://www.genengnews.com/gen-news-highlights/stem-cells-created-by-cloning-get-mitochondrial-baggage-check/81250629/

Do cells of the same type in different species act differently with the same DNA?
Short answer? yes. At least they should if you modeled the donor cells to play by the same set of rules as the receiver.

You are probably asking these questions due to reading up on human brain cells in a mouse. Right?

Gauging the community?

Humanized pig and monkey organs and tissues come to mind when thinking about your question.

There could be a rejection as enucleated (donor cells without a nucleus) has a different mtDNA and when nucleated (with a receiver nucleus) can stand out against the background mtDNA setting, post auto grafting.

There were cases of snake genes sneaking into the bovine genome. I don't know about their expression in the bovine genome. Different codon usage, maybe even different intron usage. Definitely different mammalian tRNA usage in mitochondrion. Some of the aa deviates from the rest. Turns out your immune system can tell its mitochondria from non self mitochondria.