Open-source and do-it-yourself microfluidics
Markos
Open-source and do-it-yourself microfluidics
https://doi.org/10.1016/j.snb.2021.130624
The field of microfluidics has progressed rapidly over the last few decades as an essential tool in many areas of experimental research that involve tiny liquid volumes. However, the fast-growing field relies heavily on specialized fabrication facilities and research equipment, which limits the active participation of researchers and beginners outside microfluidics. With the growing paradigm on do-it-yourself (DIY) biology and open-source (OS) hardware, there are many efforts to create microfluidic products by using publicly-shared or easy-to-use principles. Although this approach to technology innovation has already been initiated in the field of microfluidics, the literature on OS and DIY microfluidics is still disseminated in individual journals. In this review, we provide an overview of OS and DIY microfluidics and related technologies, in particular, how microfluidic devices can be fabricated without specialized manufacturing equipment and microfabrication facilities, and how laboratory equipment that is required to perform microfluidics research can be recreated to be affordable and customizable without specialized expertise. Thus, this review introduces subtractive and additive micromachining technologies such as laser cutting, milling, and 3D printing that are accessible even to beginners, and compare their pros and cons for microfabrication. Then, OS and DIY instruments essential for operation of microfluidic devices including precision pumps, microscopes, and centrifuges are reviewed. We discuss the challenges associated with the more-accessible, wide-spread use of microfluidics as well as potential strategies to address these challenges, which can lead to individual- and community-driven microfluidics innovation.
S James Parsons Jr
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Filip Hasecke
The 'usual source' for paywalled articles does not have it yet.
Thanks in advance and best regards,
P.S: Kind of paradoxical to hide a DIY paper behind a paywall. ;)
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Filip Hasecke
PhD fellow
Institute of Physical Biology
Heinrich-Heine-University
Building 26.12, Ebene U1, Raum 78
Universitätstraße 1
40225 Düsseldorf
Deutschland
Tel.: +49 211 81-15966
Markos
Hi James,
Try this:
https://www.sciencedirect.com/science/article/abs/pii/S0925400521011928?via%3Dihub
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Markos
Hi Filip,
I'm also not able to get this paper as I use the same "usual source".
But the latest papers take some time to become "accessible".
I sent an email to the authors but still didn't receive a reply.
Some respond and send the pdf.
Best Regards,
Markos
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