Fwd: Proposal for in two weeks from 10/30/13

[Eugen Leitl]

---------- Forwarded message ----------
From: Yuriy Fazylov <yuriy...@gmail.com>
Date: Tue, Oct 29, 2013 at 7:13 AM
Subject: Proposal for in two weeks from 10/30/13
To: "coast-to-coas...@googlegroups.com" <coast-to-coas...@googlegroups.com>

I know I haven't been very active in meet-ups but I would like to invite J. Christopher Anderson an investigator and author of "Modular Design of a Synthetic Payload Delivery Device." The paper was submitted to ACS journal of synthetic biology (it's PDF is down below). I believe the project was started for iGEM. I found it to be a very interesting read especially when it comes to synthetic biology and in situ & in vivo medicine synthesis and delivery. I asked Dr. Anderson some questions on him willing to join the discussion. He seemed ok with the idea. Let me know if that would be ok with you, the group.

I am very excited about this technology. I believe it is a Swiss Army knife that can be fine tuned to do procedures as complex as surgery on a microscopic scale.  I have a ton of ideas on what it can and potentially could do. For example a cell can build up mass it can no longer sustain or destroy. Translational machinery don't proofread. Post transcriptional errors may occur. The cytoplasm is a high speed place where anything can brake. With the right type of a targeting system on a gram-negative extra cellular vesicles bound for lysosomal mammalian cell compartment, it can be secreted to assist in degradation of such mass. 

P.S. This is where I originally noticed mention of the 11 new proteins associated with alzheimer's; http://creativenesswithahmed.blogspot.com/2013/10/11-new-risk-genes-for-alzheimers.html identifies new proteins and pathways for Alzheimer's. I know quite a few of you wanted to work on how to cure that. To cut to the chase go to; http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2802.html

P.S.S; I recently noticed that a video on SENS organization's YouTube channel George Church mentions CRISPR-Cas to regulate transcription of any particular gene by methylating it via recombinant Cas+methylating agent system. I don't recall/know if the work was published yet. 

P.S^3; if I ever show signs of hijacking this biweekly discussion, pushing for papers that interest me more than anyone else, let me know. 

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