Journal Club - next Wed Oct 2nd

[Nina DiPrimio]

Hello all-

Journal Club is next Wednesday, Oct 2nd at 5:30pm EST. 

John Schloendorn will be reviewing the following paper:

Long-term eff ects of Aβ42 immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial

Clive Holmes, et al.

Summary: Background Immunisation of patients with Alzheimer’s disease with full-length amyloid-β peptide (Aβ42) can clear amyloid plaques from the brain. Our aim was to assess the relation between Aβ42 immune response, degree of plaque removal, and long-term clinical outcomes.

One claim made in the paper is that patients "with virtually complete plaque removal, had severe end stage dementia." John would like us to discuss this claim, and determine if really supported by the data. If yes, how? If not, what else might the data mean?

Look forward to a wonderful discussion. Please make sure to make a zoom.us account to join the discussion. 

The paper is attached! 

Thanks.
Nina

--
Nina DiPrimio, PhD
Anderson Lab
Department of Bioengineering
UC Berkeley

Lab Phone- 510-664-4200

[Derek Jacoby]

I presume this is actually 5:30 PST rather than EST. Here is a zoom.us meeting link!

https://zoom.us/j/189777898

Thx,

Derek

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[Nina DiPrimio]

Thank you Derek - for catching the error and for sending the zoom.us link!

Journal club is 5:30pm PST, next Wednesday.

Hope to see you all there.

N

[Derek Jacoby]

You bet. BTW. I had an article come across my news feed earlier this week that makes the claim that the plaques are not the driving cause of dementia, but that other beta amyloid interactions effect cognition long before plaques even appear. Mouse study, but interesting.

http://www.sciencedaily.com/releases/2013/09/130919142156.htm

(let me know if anyone wants the paper - the pdf is almost 3 meg so I didn't want to just attach it in case some are reading this on wireless, etc.)

Thx,

--Derek

[Roger Stager]

Hello All-

Following up on the discussion  from our last meeting,  I have uploaded the recording of the meeting to YouTube (see the link below).  The video is a little jerky at times, but the audio quality seems fairly good.  If you have a chance, please let me know if you are able to view this.  If you would like to subscribe, I also created a channel for us to use for future videos . You can follow the second link to subscribe.

Roger

Link to Video

https://www.youtube.com/watch?v=2I9hrLVM2YE

Link to Channel 

https://www.youtube.com/channel/UCzHTL-e7gJD_Zy85uQmpUZA